Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice

Comparison with lewis rat lines

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Abstract

Myelin basic protein (BP)-specific T-cell lines were selected from SJL/J mice using techniques to select similar lines from Lewis rats. SJL/J BP-specific T-cell lines were composed of T cells with the helper/inducer phenotype (Lyt 1.2+, 2.2- and L3T4+) and proliferated in response to both the 1-37 and the 89-169 fragments of guinea pig BP. BP-specific T-cell lines transferred delayed-type hypersensitivity (DTH) responses to BP that persisted for over 60 days. Most recipient animals ( 32 41) developed acute experimental autoimmune encephalomyelitis (EAE), and most survivors ( 19 24) developed chronic relapsing EAE. Spinal cords of animals during both the acute and the chronic phases of illness contained plaques of demyelination and infiltrates of lymphocytes and macrophages. These findings differed from those of Lewis rat BP-specific lines which respond to a different region of BP, transfer DTH responses that last less than 12 days, and induce acute EAE in which demyelination does not occur.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
JournalCellular Immunology
Volume112
Issue number2
DOIs
StatePublished - Apr 1 1988

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Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Cell Line
Proteins
Delayed Hypersensitivity
Demyelinating Diseases
Myelin Basic Protein
Helper-Inducer T-Lymphocytes
Spinal Cord
Guinea Pigs
Chronic Disease
Macrophages
Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

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title = "Basic protein-specific T-cell lines that induce experimental autoimmune encephalomyelitis in SJL/J mice: Comparison with lewis rat lines",
abstract = "Myelin basic protein (BP)-specific T-cell lines were selected from SJL/J mice using techniques to select similar lines from Lewis rats. SJL/J BP-specific T-cell lines were composed of T cells with the helper/inducer phenotype (Lyt 1.2+, 2.2- and L3T4+) and proliferated in response to both the 1-37 and the 89-169 fragments of guinea pig BP. BP-specific T-cell lines transferred delayed-type hypersensitivity (DTH) responses to BP that persisted for over 60 days. Most recipient animals ( 32 41) developed acute experimental autoimmune encephalomyelitis (EAE), and most survivors ( 19 24) developed chronic relapsing EAE. Spinal cords of animals during both the acute and the chronic phases of illness contained plaques of demyelination and infiltrates of lymphocytes and macrophages. These findings differed from those of Lewis rat BP-specific lines which respond to a different region of BP, transfer DTH responses that last less than 12 days, and induce acute EAE in which demyelination does not occur.",
author = "Dennis Bourdette and Arthur Vandenbark and Charles Meshul and Ruth Whitham and Halina Offner",
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T2 - Comparison with lewis rat lines

AU - Bourdette, Dennis

AU - Vandenbark, Arthur

AU - Meshul, Charles

AU - Whitham, Ruth

AU - Offner, Halina

PY - 1988/4/1

Y1 - 1988/4/1

N2 - Myelin basic protein (BP)-specific T-cell lines were selected from SJL/J mice using techniques to select similar lines from Lewis rats. SJL/J BP-specific T-cell lines were composed of T cells with the helper/inducer phenotype (Lyt 1.2+, 2.2- and L3T4+) and proliferated in response to both the 1-37 and the 89-169 fragments of guinea pig BP. BP-specific T-cell lines transferred delayed-type hypersensitivity (DTH) responses to BP that persisted for over 60 days. Most recipient animals ( 32 41) developed acute experimental autoimmune encephalomyelitis (EAE), and most survivors ( 19 24) developed chronic relapsing EAE. Spinal cords of animals during both the acute and the chronic phases of illness contained plaques of demyelination and infiltrates of lymphocytes and macrophages. These findings differed from those of Lewis rat BP-specific lines which respond to a different region of BP, transfer DTH responses that last less than 12 days, and induce acute EAE in which demyelination does not occur.

AB - Myelin basic protein (BP)-specific T-cell lines were selected from SJL/J mice using techniques to select similar lines from Lewis rats. SJL/J BP-specific T-cell lines were composed of T cells with the helper/inducer phenotype (Lyt 1.2+, 2.2- and L3T4+) and proliferated in response to both the 1-37 and the 89-169 fragments of guinea pig BP. BP-specific T-cell lines transferred delayed-type hypersensitivity (DTH) responses to BP that persisted for over 60 days. Most recipient animals ( 32 41) developed acute experimental autoimmune encephalomyelitis (EAE), and most survivors ( 19 24) developed chronic relapsing EAE. Spinal cords of animals during both the acute and the chronic phases of illness contained plaques of demyelination and infiltrates of lymphocytes and macrophages. These findings differed from those of Lewis rat BP-specific lines which respond to a different region of BP, transfer DTH responses that last less than 12 days, and induce acute EAE in which demyelination does not occur.

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