Basic Physiology of Macaca mulatta

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The rhesus macaque (. Macaca mulatta) is an Asian Old World nonhuman primate species frequently used in biomedical research, predominately in the study of neuroscience, infectious disease, immunology, and reproductive physiology. They are medium sized, have relatively stout bodies, and exhibit moderate sexual dimorphism. The average weight of males is 7.7. kg and of females is 5.3. kg. In the wild, they live in multimale/multifemale groups. Females form dominance hierarchies based on matrilineal kinship. They are seasonal breeders of relatively low fecundity, with a single infant produced per pregnancy. Gestation is 165 days and sexual maturity is reached at 3-5 years of age in females and 4-6 years of age in males. In this chapter, cardiovascular, respiratory, neurologic, reproductive, immunologic, and gastrointestinal function, as well as methods of assessment and normal values, are reviewed.

    Original languageEnglish (US)
    Title of host publicationThe Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
    PublisherElsevier Inc.
    Pages87-113
    Number of pages27
    ISBN (Electronic)9780124171466
    ISBN (Print)9780124171442
    DOIs
    StatePublished - Mar 12 2015

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    Keywords

    • Cardiovascular
    • Gastrointestinal function
    • Macaca mulatta
    • Physiology
    • Reproduction
    • Respiratory
    • Rhesus macaque

    ASJC Scopus subject areas

    • Medicine(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Lewis, A. D., & Prongay, K. (2015). Basic Physiology of Macaca mulatta. In The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment (pp. 87-113). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-417144-2.00006-8