Basement membrane diversity detected by monoclonal antibodies

Helena Hessle, Lynn Y. Sakai, David W. Hollister, Robert E. Burgeson, Eva Engvall

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Human fetal membranes or pepsin solubilized proteins thereof were used as immunogens in the production of monoclonal antibodies to basement membrane-associated components. Some of the antibodies obtained reacted with all basement membranes in indirect immunofluorescent-cent microscopy, others reacted with all epithelial but not with endothelial basement membranes, and yet other antibodies reacted only with certain epithelial basement membranes in these tests. The reactivities of the antibodies demonstrate that different basement membranes are (immuno)chemically different and contain unique components in addition to ubiquitous components such as type IV collagen and laminin

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
Issue number1-3
StatePublished - 1984

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research


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