Basement membrane assembly, stability and activities observed through a developmental lens

Peter D. Yurchenco, Peter S. Amenta, Bruce Patton

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Basement membranes are cell surface associated extracellular matrices containing laminins, type IV collagens, nidogens, perlecan, agrin, and other macromolecules. Biochemical and ultrastructural studies have suggested that basement membrane assembly and integrity is provided through multiple component interactions consisting of self-polymerizations, inter-component binding, and cell surface adhesions. Mutagenesis in vertebrate embryos and embryoid bodies have led to revisions of this model, providing evidence that laminins are essential for the formation of an initial polymeric scaffold of cell-attached matrix which matures in stability, ligand diversity, and functional complexity as additional matrix components are integrated into the scaffold. These studies also demonstrate that basement membrane components differentially promote cell polarization, organize and compartmentalize developing tissues, and maintain adult tissue function.

Original languageEnglish (US)
Pages (from-to)521-538
Number of pages18
JournalMatrix Biology
Volume22
Issue number7
DOIs
StatePublished - Jan 2004

Fingerprint

Basement Membrane
Lenses
Laminin
Agrin
Embryoid Bodies
Collagen Type IV
Cell Adhesion
Mutagenesis
Polymerization
Extracellular Matrix
Vertebrates
Embryonic Structures
Ligands

Keywords

  • Basement membrane
  • Laminins
  • Mutagenesis

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Basement membrane assembly, stability and activities observed through a developmental lens. / Yurchenco, Peter D.; Amenta, Peter S.; Patton, Bruce.

In: Matrix Biology, Vol. 22, No. 7, 01.2004, p. 521-538.

Research output: Contribution to journalArticle

Yurchenco, Peter D. ; Amenta, Peter S. ; Patton, Bruce. / Basement membrane assembly, stability and activities observed through a developmental lens. In: Matrix Biology. 2004 ; Vol. 22, No. 7. pp. 521-538.
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