Basal nitric oxide production in regulation of cochlear blood flow

P. B. Brechtelsbauer, Alfred Nuttall, J. M. Miller

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Nitric oxide (NO), recently identified as endothelium-derived relaxing factor, has been shown to influence both vascular and neural function. In blood vessels, NO is produced by endothelial and smooth muscle cells and may play a role in regulation of cochlear blood flow. In the central nervous system, NO functions as a neurotransmitter involved in long term potentiation. The principle hypothesis tested in this study was that basal NO production in the cochlear blood vessels contributes to regulation of CBF. Since NO is a vasodilator, diminished NO synthesis may decrease the level of CBF. Application of a competitive inhibitor of NO synthase either intravenously or to the round window membrane caused a reduction in CBF. The application to the round window membrane did not affect compound action potential thresholds. With intravenous adminstration, the effect on CBF was dose-related and could be reversed with the physiologic substrate, l-arginine. These data indicate that NO is produced in the cochlear blood vessels and contributes to the regulation of CBF.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalHearing Research
Volume77
Issue number1-2
DOIs
StatePublished - Jun 15 1994
Externally publishedYes

Fingerprint

Cochlea
Nitric Oxide
Blood Vessels
Endothelium-Dependent Relaxing Factors
Membranes
Long-Term Potentiation
Vasodilator Agents
Nitric Oxide Synthase
Action Potentials
Smooth Muscle Myocytes
Neurotransmitter Agents
Arginine
Central Nervous System

Keywords

  • Compound action potential
  • Guinea Pig
  • l-arginine
  • Ng-nitro-l-arginine

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Basal nitric oxide production in regulation of cochlear blood flow. / Brechtelsbauer, P. B.; Nuttall, Alfred; Miller, J. M.

In: Hearing Research, Vol. 77, No. 1-2, 15.06.1994, p. 38-42.

Research output: Contribution to journalArticle

Brechtelsbauer, P. B. ; Nuttall, Alfred ; Miller, J. M. / Basal nitric oxide production in regulation of cochlear blood flow. In: Hearing Research. 1994 ; Vol. 77, No. 1-2. pp. 38-42.
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