Basal nitric oxide production in regulation of cochlear blood flow

P. B. Brechtelsbauer, A. L. Nuttall, J. M. Miller

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Nitric oxide (NO), recently identified as endothelium-derived relaxing factor, has been shown to influence both vascular and neural function. In blood vessels, NO is produced by endothelial and smooth muscle cells and may play a role in regulation of cochlear blood flow. In the central nervous system, NO functions as a neurotransmitter involved in long term potentiation. The principle hypothesis tested in this study was that basal NO production in the cochlear blood vessels contributes to regulation of CBF. Since NO is a vasodilator, diminished NO synthesis may decrease the level of CBF. Application of a competitive inhibitor of NO synthase either intravenously or to the round window membrane caused a reduction in CBF. The application to the round window membrane did not affect compound action potential thresholds. With intravenous adminstration, the effect on CBF was dose-related and could be reversed with the physiologic substrate, l-arginine. These data indicate that NO is produced in the cochlear blood vessels and contributes to the regulation of CBF.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalHearing Research
Volume77
Issue number1-2
DOIs
StatePublished - Jun 15 1994

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Keywords

  • Compound action potential
  • Guinea Pig
  • Ng-nitro-l-arginine
  • l-arginine

ASJC Scopus subject areas

  • Sensory Systems

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