Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset

Stephen Correia; Emily Hubbard; Jason Hassenstab; Agustin Yip; Josef Vymazal; Vit Herynek; Jay Giedd; Dennis L. Murphy; Benjamin D. Greenberg

doi:10.1007/s11682-009-9083-2

Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset

Stephen Correia, Emily Hubbard, Jason Hassenstab, Agustin Yip, Josef Vymazal, Vit Herynek, Jay Giedd, Dennis L. Murphy, Benjamin D. Greenberg

Family Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.

Original language	English (US)
Pages (from-to)	35-45
Number of pages	11
Journal	Brain Imaging and Behavior
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/s11682-009-9083-2
State	Published - Mar 2010

Keywords

Age of onset
Basal ganglia
Iron
Magnetic Resonance Imaging
Obsessive-compulsive disorder

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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10.1007/s11682-009-9083-2

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title = "Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset",

abstract = "Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.",

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note = "Funding Information: Acknowledgments We wish to thank David Strong, Ph.D. for his contribution to the statistical analyses. This work was supported by the Intramural Research Program at the National Institute of Mental Health and the Department of Veterans Affairs. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States.",

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AU - Herynek, Vit

AU - Giedd, Jay

AU - Murphy, Dennis L.

AU - Greenberg, Benjamin D.

N1 - Funding Information: Acknowledgments We wish to thank David Strong, Ph.D. for his contribution to the statistical analyses. This work was supported by the Intramural Research Program at the National Institute of Mental Health and the Department of Veterans Affairs. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States.

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N2 - Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.

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Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset

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