TY - JOUR
T1 - Barrett’s-related esophageal adenocarcinoma
T2 - Is chemoprevention a potential option?
AU - Fennerty, M. Brian
AU - Triadafilopoulos, George
PY - 2001/8
Y1 - 2001/8
N2 - OBJECTIVE: Review the rationale behind secondary prevention of Barrett’s related esophageal adenocarcinoma and critically appraise the emerging literature regarding prevention of neoplasia in Barrett’s esophagus with antisecretory and/or cyclo-oxygenase inhibition therapy. METHODS: The existing English language literature regarding secondary cancer prevention in patients with Barrett’s esophagus is reviewed and its potential clinical implications discussed. RESULTS: There is biologic plausibility to pursue “chemo-prevention” trials with antisecretory and/or cyclo-oxygenase inhibition therapy in patients with Barrett’s esophagus. CONCLUSION: Chemoprevention trials using potent antisecretory therapy coupled with cyclo-oxygenase 2 inhibition are warranted and may provide a means of decreasing the occurrence of cancer and cancer-related mortality in this disease.
AB - OBJECTIVE: Review the rationale behind secondary prevention of Barrett’s related esophageal adenocarcinoma and critically appraise the emerging literature regarding prevention of neoplasia in Barrett’s esophagus with antisecretory and/or cyclo-oxygenase inhibition therapy. METHODS: The existing English language literature regarding secondary cancer prevention in patients with Barrett’s esophagus is reviewed and its potential clinical implications discussed. RESULTS: There is biologic plausibility to pursue “chemo-prevention” trials with antisecretory and/or cyclo-oxygenase inhibition therapy in patients with Barrett’s esophagus. CONCLUSION: Chemoprevention trials using potent antisecretory therapy coupled with cyclo-oxygenase 2 inhibition are warranted and may provide a means of decreasing the occurrence of cancer and cancer-related mortality in this disease.
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U2 - 10.1016/S0002-9270(01)02596-5
DO - 10.1016/S0002-9270(01)02596-5
M3 - Review article
C2 - 11513166
AN - SCOPUS:0034887528
SN - 0002-9270
VL - 96
SP - 2302
EP - 2305
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -