Barrett's esophagus in Latinos undergoing endoscopy for gastroesophageal reflux disease symptoms

Kian Keyashian, V. Hua, K. Narsinh, M. Kline, P. T. Chandrasoma, J. J. Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous studies comparing the prevalence of Barrett's esophagus in Latinos and non-Latino whites are inconsistent. The aim of the study is to compare the prevalence of Barrett's esophagus in Latinos and non-Latino whites and to determine risk factors associated with Barrett's esophagus. Between March 2005 and January 2009, consecutive Latino and non-Latino white patients who underwent endoscopy for primary indication for symptoms of gastroesophageal reflux disease were identified by examining the internal endoscopy database at Los Angeles County+USC Medical Center. Barrett's esophagus was defined by columnar-lined distal esophagus on endoscopy confirmed by intestinal metaplasia on histology. Clinical features and endoscopic findings were retrospectively reviewed. The mean age of the 663 patients was 50±12years, 30% were male, and 92% were Latino. Compared with non-Latino whites, Latinos had more females (72% vs. 46%; P=0.0001) and more Helicobacter pylori infection (53% vs. 24%; P=0.003) but less tobacco use (7% vs. 17%; P=0.01). Overall, 10% (68/663) of all patients had Barrett's esophagus whereas the prevalence was 10% (62/611) among the Latinos and 12% (6/52) among the non-Latino whites (OR 0.9, 95% CI 0.4-2.1; P=0.75). One patient in the Latino group had high-grade dysplasia. On multivariate analysis, male gender (AOR 2.3, 95% CI 1.4-4.1; P=0.002), diabetes (AOR 2.2, 95% CI 1.1-4.5; P=0.03), and age ≥55 years (AOR 2.2, 95% CI 1.3-3.8; P=0.006) were independently associated with Barrett's esophagus; Latino ethnicity remained nonsignificant (AOR 1.1, 95% CI 0.4-2.7; P=0.88). In Latinos undergoing endoscopy for gastroesophageal reflux disease symptoms, the prevalence of Barrett's esophagus was 10%, comparable with non-Latino white controls as well as the prevalence previously reported among Caucasians. In addition to established risk factors, diabetes was associated with Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalDiseases of the Esophagus
Volume26
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Barrett Esophagus
Gastroesophageal Reflux
Hispanic Americans
Endoscopy
Los Angeles
Metaplasia
Tobacco Use
Helicobacter Infections
Helicobacter pylori
Esophagus
Histology
Multivariate Analysis
Cross-Sectional Studies
Databases

Keywords

  • Barrett's esophagus
  • Gastroesophageal reflux disease
  • Hispanic
  • Latino
  • Screening

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Barrett's esophagus in Latinos undergoing endoscopy for gastroesophageal reflux disease symptoms. / Keyashian, Kian; Hua, V.; Narsinh, K.; Kline, M.; Chandrasoma, P. T.; Kim, J. J.

In: Diseases of the Esophagus, Vol. 26, No. 1, 01.2013, p. 44-49.

Research output: Contribution to journalArticle

Keyashian, Kian ; Hua, V. ; Narsinh, K. ; Kline, M. ; Chandrasoma, P. T. ; Kim, J. J. / Barrett's esophagus in Latinos undergoing endoscopy for gastroesophageal reflux disease symptoms. In: Diseases of the Esophagus. 2013 ; Vol. 26, No. 1. pp. 44-49.
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