Barbiturate withdrawal and magnesium deficiency in mice

John Belknap, J. H. Berg, G. Ondrusek, S. Waddingham

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

C57BL/6J male mice rendered physically dependent on phenobarbital exhibited significantly lower whole-brain and serum-magnesium concentrations than did control mice. The symptoms of phenobarbital withdrawal were remarkably similar to those seen in magnesium-deficient mice exposed to a low-magnesium diet without drug exposure. These findings suggest that brain magnesium deficits produced by chronic phenobarbital withdrawal could contribute to the observed phenobarbital withdrawal syndrome. Administration of MgSO4 during withdrawal significantly reduced the incidence of tonic-clonic and lethal tonic seizures.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalPsychopharmacology
Volume59
Issue number3
DOIs
StatePublished - Jan 1978
Externally publishedYes

Fingerprint

Magnesium Deficiency
Phenobarbital
Magnesium
Substance Withdrawal Syndrome
Brain
Seizures
Diet
barbituric acid
Incidence
Serum
Pharmaceutical Preparations

Keywords

  • Barbiturate withdrawal
  • Magnesium deficiency
  • Physical dependence

ASJC Scopus subject areas

  • Pharmacology

Cite this

Belknap, J., Berg, J. H., Ondrusek, G., & Waddingham, S. (1978). Barbiturate withdrawal and magnesium deficiency in mice. Psychopharmacology, 59(3), 299-303. https://doi.org/10.1007/BF00426638

Barbiturate withdrawal and magnesium deficiency in mice. / Belknap, John; Berg, J. H.; Ondrusek, G.; Waddingham, S.

In: Psychopharmacology, Vol. 59, No. 3, 01.1978, p. 299-303.

Research output: Contribution to journalArticle

Belknap, J, Berg, JH, Ondrusek, G & Waddingham, S 1978, 'Barbiturate withdrawal and magnesium deficiency in mice', Psychopharmacology, vol. 59, no. 3, pp. 299-303. https://doi.org/10.1007/BF00426638
Belknap J, Berg JH, Ondrusek G, Waddingham S. Barbiturate withdrawal and magnesium deficiency in mice. Psychopharmacology. 1978 Jan;59(3):299-303. https://doi.org/10.1007/BF00426638
Belknap, John ; Berg, J. H. ; Ondrusek, G. ; Waddingham, S. / Barbiturate withdrawal and magnesium deficiency in mice. In: Psychopharmacology. 1978 ; Vol. 59, No. 3. pp. 299-303.
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