Barbiturate physical dependence in mice: Effects of neuroleptics and diazepam on the withdrawal syndrome

J. K. Belknap

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Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice. In contrast, the neuroleptic agents employed (chlorpromazine, haloperidol, or reserpine) or αmethyl-p-tyrosine tended to exacerbate the withdrawal syndrome. Chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawal symptoms.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalClinical Toxicology
Issue number4
StatePublished - Jan 1 1978


ASJC Scopus subject areas

  • Toxicology

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