Abstract
Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice. In contrast, the neuroleptic agents employed (chlorpromazine, haloperidol, or reserpine) or αmethyl-p-tyrosine tended to exacerbate the withdrawal syndrome. Chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawal symptoms.
Original language | English (US) |
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Pages (from-to) | 427-434 |
Number of pages | 8 |
Journal | Clinical Toxicology |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Toxicology