Barbiturate dependence in mice induced by a simple short term oral procedure

John Belknap, S. Waddingham, G. Ondrusek

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A procedure for inducing phenobarbital (PB) dependence in mice is presented, using an adulterated milled diet. Marked withdrawal symptoms, including convulsions, were readily produced. In comparison with C57BL/6J mice, DBA/2J mice showed markedly greater intoxication and withdrawal, while consuming less PB during the same period. Thus, DBA/2J animals showed a more heightened sensitivity to PB dependence than did C57BL/6J animals.

Original languageEnglish (US)
Pages (from-to)394-396
Number of pages3
JournalPhysiological Psychology
Volume1
Issue number4
StatePublished - 1973
Externally publishedYes

Fingerprint

Phenobarbital
Substance Withdrawal Syndrome
Inbred DBA Mouse
Inbred C57BL Mouse
Seizures
Diet
barbituric acid

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Belknap, J., Waddingham, S., & Ondrusek, G. (1973). Barbiturate dependence in mice induced by a simple short term oral procedure. Physiological Psychology, 1(4), 394-396.

Barbiturate dependence in mice induced by a simple short term oral procedure. / Belknap, John; Waddingham, S.; Ondrusek, G.

In: Physiological Psychology, Vol. 1, No. 4, 1973, p. 394-396.

Research output: Contribution to journalArticle

Belknap, J, Waddingham, S & Ondrusek, G 1973, 'Barbiturate dependence in mice induced by a simple short term oral procedure', Physiological Psychology, vol. 1, no. 4, pp. 394-396.
Belknap, John ; Waddingham, S. ; Ondrusek, G. / Barbiturate dependence in mice induced by a simple short term oral procedure. In: Physiological Psychology. 1973 ; Vol. 1, No. 4. pp. 394-396.
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