TY - JOUR
T1 - Barbiturate dependence in mice induced by a simple short-term oral procedure
AU - Belknap, J. K.
AU - Waddingham, Stephanie
AU - Ondrusek, Gene
PY - 1973/12
Y1 - 1973/12
N2 - A procedure for inducing phenobarbital (PB) dependence in mice is presented, using an adulterated milled diet. Marked withdrawal symptoms, including convulsions, were readily produced. In comparison with C57BL/6J mice, DBA/2J mice showed markedly greater intoxication and withdrawal, while consuming less PB during the same period. Thus, DBA/2J animals showed a heightened sensitivity to PB dependence than did C57BL/6J animals.
AB - A procedure for inducing phenobarbital (PB) dependence in mice is presented, using an adulterated milled diet. Marked withdrawal symptoms, including convulsions, were readily produced. In comparison with C57BL/6J mice, DBA/2J mice showed markedly greater intoxication and withdrawal, while consuming less PB during the same period. Thus, DBA/2J animals showed a heightened sensitivity to PB dependence than did C57BL/6J animals.
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U2 - 10.3758/BF03326951
DO - 10.3758/BF03326951
M3 - Article
AN - SCOPUS:0015733720
SN - 0090-5046
VL - 1
SP - 394
EP - 396
JO - Physiological Psychology
JF - Physiological Psychology
IS - 4
ER -