Barbiturate dependence in mice induced by a simple short-term oral procedure

J. K. Belknap, Stephanie Waddingham, Gene Ondrusek

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A procedure for inducing phenobarbital (PB) dependence in mice is presented, using an adulterated milled diet. Marked withdrawal symptoms, including convulsions, were readily produced. In comparison with C57BL/6J mice, DBA/2J mice showed markedly greater intoxication and withdrawal, while consuming less PB during the same period. Thus, DBA/2J animals showed a heightened sensitivity to PB dependence than did C57BL/6J animals.

Original languageEnglish (US)
Pages (from-to)394-396
Number of pages3
JournalPhysiological Psychology
Volume1
Issue number4
DOIs
StatePublished - Dec 1973

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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