Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain

S. Waddingham, W. R. Riffee, John Belknap, J. R. Sheppard

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

C57BL/6J and DBA/2J inbred mice were assayed for β-adrenergic receptor density following 7 days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.

Original languageEnglish (US)
Pages (from-to)207-220
Number of pages14
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume20
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Inbred DBA Mouse
Phenobarbital
Adrenergic Receptors
Brain
Inbred C57BL Mouse
barbituric acid

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Barbiturate dependence in mice : Evidence for β-adrenergic receptor proliferation in brain. / Waddingham, S.; Riffee, W. R.; Belknap, John; Sheppard, J. R.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 20, No. 2, 1978, p. 207-220.

Research output: Contribution to journalArticle

Waddingham, S. ; Riffee, W. R. ; Belknap, John ; Sheppard, J. R. / Barbiturate dependence in mice : Evidence for β-adrenergic receptor proliferation in brain. In: Research Communications in Chemical Pathology and Pharmacology. 1978 ; Vol. 20, No. 2. pp. 207-220.
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