Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain

S. Waddingham, W. R. Riffee, J. K. Belknap, J. R. Sheppard

Research output: Contribution to journalArticle

2 Scopus citations


C57BL/6J and DBA/2J inbred mice were assayed for β-adrenergic receptor density following 7 days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.

Original languageEnglish (US)
Pages (from-to)207-220
Number of pages14
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number2
StatePublished - Dec 1 1978


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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