Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome

S. Waddingham; J. K. Belknap

doi:10.3181/00379727-163-40798

Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome

S. Waddingham, J. K. Belknap

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.

Original language	English (US)
Pages (from-to)	469-472
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	163
Issue number	4
DOIs	https://doi.org/10.3181/00379727-163-40798
State	Published - Apr 1980
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-163-40798

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title = "Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome",

abstract = "C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.",

author = "S. Waddingham and Belknap, {J. K.}",

note = "Funding Information: This research was supported by grants from the National Association for Mental Health and the Dight Institute for Human Genetics to the first author, and by Grant DA 01800 (NIDA) to the second author.",

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AU - Waddingham, S.

AU - Belknap, J. K.

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PY - 1980/4

Y1 - 1980/4

N2 - C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.

AB - C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.

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Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome

Abstract

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