Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome

S. Waddingham, J. K. Belknap

Research output: Contribution to journalArticle

3 Scopus citations


C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Apr 1980


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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