Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production

Donald Y M Leung, Maurice Gately, Anne Trumble, Bonnie Ferguson-Darnell, Patrick M. Schlievert, Louis Picker

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

T lymphocyte infiltration is a prominent feature of the skin inflammation associated with infections by toxin (superantigen)-secreting Staphylococcus aureus or Streptococcus bacteria. The cutaneous lymphocyte-associated antigen (CLA) has been hypothesized to be a homing receptor (HR) involved in selective migration of memory/effector T cells to the skin. Since the expression of this putative skin-selective HR is known to be under strict microenvironmental control, we sought to determine the effect of staphylococcal and streptococcal toxins on T cell expression of CLA. After in vitro stimulation of peripheral blood mononuclear cells with staphylococcal enterotoxin B, toxic shock syndrome toxin-1, and streptococcal pyrogenic exotoxins A and C, there was a significant increase in the numbers of CLA+ T cell blasts (p + T cells in an IL-12-dependent manner, and thus may contribute to the development of skin rashes in superantigen-mediated diseases.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalJournal of Experimental Medicine
Volume181
Issue number2
DOIs
StatePublished - Feb 1 1995
Externally publishedYes

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Lymphocyte Homing Receptors
Superantigens
Interleukin-12
T-Lymphocytes
Antigens
Skin
Lymphocytes
Lymphocyte Count
Exanthema
Streptococcus
Staphylococcus aureus
Blood Cells
Inflammation
Bacteria
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. / Leung, Donald Y M; Gately, Maurice; Trumble, Anne; Ferguson-Darnell, Bonnie; Schlievert, Patrick M.; Picker, Louis.

In: Journal of Experimental Medicine, Vol. 181, No. 2, 01.02.1995, p. 747-753.

Research output: Contribution to journalArticle

Leung, Donald Y M ; Gately, Maurice ; Trumble, Anne ; Ferguson-Darnell, Bonnie ; Schlievert, Patrick M. ; Picker, Louis. / Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. In: Journal of Experimental Medicine. 1995 ; Vol. 181, No. 2. pp. 747-753.
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