Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement

Michael I. Greenberg, Robert G. Hendrickson

Research output: Contribution to journalArticle

41 Scopus citations


Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalJournal of Toxicology - Clinical Toxicology
Issue number1
StatePublished - Mar 13 2003



  • Baclofen
  • GABA B agonist
  • Intrathecal baclofen
  • Withdrawal

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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