Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement

Michael I. Greenberg; Robert G. Hendrickson

doi:10.1081/CLT-120018277

Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement

Michael I. Greenberg, Robert G. Hendrickson

Emergency Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.

Original language	English (US)
Pages (from-to)	83-85
Number of pages	3
Journal	Journal of Toxicology - Clinical Toxicology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1081/CLT-120018277
State	Published - Mar 13 2003

Keywords

Baclofen
GABA B agonist
Intrathecal baclofen
Withdrawal

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

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AB - Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead to the development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.

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Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement

Abstract

Keywords

ASJC Scopus subject areas

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