Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study

Christopher Lee, James Mudd, Jill Gelow, Thuan Nguyen, Shirin O. Hiatt, Jennifer K. Green, Quin Denfeld, Julie T. Bidwell, Kathleen L. Grady

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Unexplained heterogeneity in response to ventricular assist device (VAD) implantation for the management of advanced heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education, and personalize monitoring and symptom management strategies. The purpose of this article was to describe the background and the design of a study entitled "Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure" (PREMISE). Study Design and Methods: PREMISE is a prospective cohort study designed to (1) identify common and distinct trajectories of change in physical and psychological symptom burden; (2) characterize common trajectories of change in serum biomarkers of myocardial stress, systemic inflammation, and endothelial dysfunction; and (3) quantify associations between symptoms and biomarkers of pathogenesis in adults undergoing VAD implantation. Latent growth mixture modeling, including parallel process and cross-classification modeling, will be used to address the study aims and will entail identifying trajectories, quantifying associations between trajectories and both clinical and quality-of-life outcomes, and identifying predictors of favorable symptom and biomarker responses to VAD implantation. Conclusions: Research findings from the PREMISE study will be used to enhance shared patient and provider decision making and to shape a much-needed new breed of interventions and clinical management strategies that are tailored to differential symptom and pathogenic responses to VAD implantation.

Original languageEnglish (US)
Pages (from-to)405-415
Number of pages11
JournalJournal of Cardiovascular Nursing
Volume29
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Heart-Assist Devices
Heart Failure
Biomarkers
Aptitude
Patient Education
Decision Making
Cohort Studies
Quality of Life
Prospective Studies
Psychology
Inflammation
Growth
Serum
Research

Keywords

  • Advanced heart failure
  • Mechanical circulatory support
  • Symptom biochemistry
  • Ventricular assist device

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine

Cite this

Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study. / Lee, Christopher; Mudd, James; Gelow, Jill; Nguyen, Thuan; Hiatt, Shirin O.; Green, Jennifer K.; Denfeld, Quin; Bidwell, Julie T.; Grady, Kathleen L.

In: Journal of Cardiovascular Nursing, Vol. 29, No. 5, 2014, p. 405-415.

Research output: Contribution to journalArticle

Lee, Christopher ; Mudd, James ; Gelow, Jill ; Nguyen, Thuan ; Hiatt, Shirin O. ; Green, Jennifer K. ; Denfeld, Quin ; Bidwell, Julie T. ; Grady, Kathleen L. / Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study. In: Journal of Cardiovascular Nursing. 2014 ; Vol. 29, No. 5. pp. 405-415.
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