Abstract
Background: Unexplained heterogeneity in response to ventricular assist device (VAD) implantation for the management of advanced heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education, and personalize monitoring and symptom management strategies. The purpose of this article was to describe the background and the design of a study entitled "Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure" (PREMISE). Study Design and Methods: PREMISE is a prospective cohort study designed to (1) identify common and distinct trajectories of change in physical and psychological symptom burden; (2) characterize common trajectories of change in serum biomarkers of myocardial stress, systemic inflammation, and endothelial dysfunction; and (3) quantify associations between symptoms and biomarkers of pathogenesis in adults undergoing VAD implantation. Latent growth mixture modeling, including parallel process and cross-classification modeling, will be used to address the study aims and will entail identifying trajectories, quantifying associations between trajectories and both clinical and quality-of-life outcomes, and identifying predictors of favorable symptom and biomarker responses to VAD implantation. Conclusions: Research findings from the PREMISE study will be used to enhance shared patient and provider decision making and to shape a much-needed new breed of interventions and clinical management strategies that are tailored to differential symptom and pathogenic responses to VAD implantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-415 |
| Number of pages | 11 |
| Journal | Journal of Cardiovascular Nursing |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Advanced heart failure
- Mechanical circulatory support
- Symptom biochemistry
- Ventricular assist device
ASJC Scopus subject areas
- Advanced and Specialized Nursing
- Cardiology and Cardiovascular Medicine
Cite this
Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study. / Lee, Christopher; Mudd, James; Gelow, Jill; Nguyen, Thuan; Hiatt, Shirin O.; Green, Jennifer K.; Denfeld, Quin; Bidwell, Julie T.; Grady, Kathleen L.
In: Journal of Cardiovascular Nursing, Vol. 29, No. 5, 2014, p. 405-415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study
AU - Lee, Christopher
AU - Mudd, James
AU - Gelow, Jill
AU - Nguyen, Thuan
AU - Hiatt, Shirin O.
AU - Green, Jennifer K.
AU - Denfeld, Quin
AU - Bidwell, Julie T.
AU - Grady, Kathleen L.
PY - 2014
Y1 - 2014
N2 - Background: Unexplained heterogeneity in response to ventricular assist device (VAD) implantation for the management of advanced heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education, and personalize monitoring and symptom management strategies. The purpose of this article was to describe the background and the design of a study entitled "Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure" (PREMISE). Study Design and Methods: PREMISE is a prospective cohort study designed to (1) identify common and distinct trajectories of change in physical and psychological symptom burden; (2) characterize common trajectories of change in serum biomarkers of myocardial stress, systemic inflammation, and endothelial dysfunction; and (3) quantify associations between symptoms and biomarkers of pathogenesis in adults undergoing VAD implantation. Latent growth mixture modeling, including parallel process and cross-classification modeling, will be used to address the study aims and will entail identifying trajectories, quantifying associations between trajectories and both clinical and quality-of-life outcomes, and identifying predictors of favorable symptom and biomarker responses to VAD implantation. Conclusions: Research findings from the PREMISE study will be used to enhance shared patient and provider decision making and to shape a much-needed new breed of interventions and clinical management strategies that are tailored to differential symptom and pathogenic responses to VAD implantation.
AB - Background: Unexplained heterogeneity in response to ventricular assist device (VAD) implantation for the management of advanced heart failure impedes our ability to predict favorable outcomes, provide adequate patient and family education, and personalize monitoring and symptom management strategies. The purpose of this article was to describe the background and the design of a study entitled "Profiling Biobehavioral Responses to Mechanical Support in Advanced Heart Failure" (PREMISE). Study Design and Methods: PREMISE is a prospective cohort study designed to (1) identify common and distinct trajectories of change in physical and psychological symptom burden; (2) characterize common trajectories of change in serum biomarkers of myocardial stress, systemic inflammation, and endothelial dysfunction; and (3) quantify associations between symptoms and biomarkers of pathogenesis in adults undergoing VAD implantation. Latent growth mixture modeling, including parallel process and cross-classification modeling, will be used to address the study aims and will entail identifying trajectories, quantifying associations between trajectories and both clinical and quality-of-life outcomes, and identifying predictors of favorable symptom and biomarker responses to VAD implantation. Conclusions: Research findings from the PREMISE study will be used to enhance shared patient and provider decision making and to shape a much-needed new breed of interventions and clinical management strategies that are tailored to differential symptom and pathogenic responses to VAD implantation.
KW - Advanced heart failure
KW - Mechanical circulatory support
KW - Symptom biochemistry
KW - Ventricular assist device
UR - http://www.scopus.com/inward/record.url?scp=84906078103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906078103&partnerID=8YFLogxK
U2 - 10.1097/JCN.0b013e318299fa09
DO - 10.1097/JCN.0b013e318299fa09
M3 - Article
C2 - 23839571
AN - SCOPUS:84906078103
VL - 29
SP - 405
EP - 415
JO - Journal of Cardiovascular Nursing
JF - Journal of Cardiovascular Nursing
SN - 0889-4655
IS - 5
ER -