B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13)

Katherine M. Falkenhagen, Rita M. Braziel, Frederick W. Fraunfelder, Justine R. Smith

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

PURPOSE: The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. DESIGN: Laboratory investigation. METHODS: CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval. RESULTS: In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine. CONCLUSIONS: B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalAmerican journal of ophthalmology
Volume140
Issue number2
DOIs
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Ophthalmology

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