B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13)

Katherine M. Falkenhagen, Rita Braziel, Frederick W. Fraunfelder, Justine R. Smith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PURPOSE: The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. DESIGN: Laboratory investigation. METHODS: CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval. RESULTS: In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine. CONCLUSIONS: B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume140
Issue number2
DOIs
StatePublished - Aug 2005

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Chemokine CXCL13
Chemokines
B-Lymphocytes
Pseudolymphoma
Biopsy
B-Cell Lymphoma
Paraffin
Dendritic Cells
Hyperplasia
Endothelial Cells
Immunohistochemistry
Lymphocytes
Antigens
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13). / Falkenhagen, Katherine M.; Braziel, Rita; Fraunfelder, Frederick W.; Smith, Justine R.

In: American Journal of Ophthalmology, Vol. 140, No. 2, 08.2005, p. 335-337.

Research output: Contribution to journalArticle

Falkenhagen, Katherine M. ; Braziel, Rita ; Fraunfelder, Frederick W. ; Smith, Justine R. / B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13). In: American Journal of Ophthalmology. 2005 ; Vol. 140, No. 2. pp. 335-337.
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