B cells and their mediators as targets for therapy in solid tumors

Andrew J. Gunderson, Lisa M. Coussens

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy.

Original languageEnglish (US)
Pages (from-to)1644-1649
Number of pages6
JournalExperimental Cell Research
Volume319
Issue number11
DOIs
StatePublished - Jul 1 2013

Keywords

  • B cells
  • Cancer
  • Inflammation
  • Leukocytes
  • Myeloid cells

ASJC Scopus subject areas

  • Cell Biology

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