B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus

R. D. Schrier, J. W. Gnann, A. J. Langlois, K. Shriver, Jay Nelson, M. B A Oldstone

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Abstract

Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609). Both immunoglobulin M (IgM) and IgG antibodies against this epitope appeared early after primary infection with HIV-1. In an animal model, the IgG response to a synthetic peptide derived from this sequence was T-helper-cell dependent, whereas the IgM response was T-cell independent. In addition, antibody generated by immunization with this peptide had HIV-1-neutralizing activity. Greater than 99% (201 to 203) of patients infected with HIV-1 generated antibody to this peptide in vivo; however, only 24% (7 of 29) had T cells that proliferated in response to this peptide in vitro. These observations suggested that different HIV-1 gp41 epitopes elicit B-cell and T-cell immune responses.

Original languageEnglish (US)
Pages (from-to)2531-2536
Number of pages6
JournalJournal of Virology
Volume62
Issue number8
Publication statusPublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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Schrier, R. D., Gnann, J. W., Langlois, A. J., Shriver, K., Nelson, J., & Oldstone, M. B. A. (1988). B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus. Journal of Virology, 62(8), 2531-2536.