Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis

for the Cysticercosis Working Group in Peru

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of Taenia solium and is the leading cause of preventable epilepsy worldwide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and as a cause of brain injury, but has not been well described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution toward understanding the pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelminthic treatment.

Original languageEnglish (US)
JournalBrain Pathology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Neurocysticercosis
Pathology
Swine
Taenia solium
Cysticercus
Parasitic Diseases
Axonal Transport
Intermediate Filaments
Amyloid beta-Protein Precursor
Brain Diseases
Neurodegenerative Diseases
Brain Injuries
Epilepsy
Injections
Brain
Infection
Therapeutics

Keywords

  • APP
  • neurocysticercosis
  • neurofilament
  • spheroids
  • T. solium oncospheres

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Axonal swellings and spheroids : a new insight into the pathology of neurocysticercosis. / for the Cysticercosis Working Group in Peru.

In: Brain Pathology, 01.01.2018.

Research output: Contribution to journalArticle

@article{54b88a6f4a4145b6a4104d504a1596f8,
title = "Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis",
abstract = "Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of Taenia solium and is the leading cause of preventable epilepsy worldwide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and as a cause of brain injury, but has not been well described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution toward understanding the pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelminthic treatment.",
keywords = "APP, neurocysticercosis, neurofilament, spheroids, T. solium oncospheres",
author = "{for the Cysticercosis Working Group in Peru} and {Mejia Maza}, Alan and Carmen-Orozco, {Rogger P.} and Carter, {Emma S.} and D{\'a}vila-Villacorta, {Danitza G.} and Gino Castillo and Morales, {Jemina D.} and Javier Mamani and Gav{\'i}dia, {Cesar M.} and Joseph Alroy and Sterling, {Charles R.} and Gonzalez, {Armando E.} and Garc{\'i}a, {H{\'e}ctor H.} and Woltjer, {Randall (Randy)} and Ver{\'a}stegui, {Manuela R.} and Gilman, {Robert H.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/bpa.12669",
language = "English (US)",
journal = "Brain Pathology",
issn = "1015-6305",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Axonal swellings and spheroids

T2 - a new insight into the pathology of neurocysticercosis

AU - for the Cysticercosis Working Group in Peru

AU - Mejia Maza, Alan

AU - Carmen-Orozco, Rogger P.

AU - Carter, Emma S.

AU - Dávila-Villacorta, Danitza G.

AU - Castillo, Gino

AU - Morales, Jemina D.

AU - Mamani, Javier

AU - Gavídia, Cesar M.

AU - Alroy, Joseph

AU - Sterling, Charles R.

AU - Gonzalez, Armando E.

AU - García, Héctor H.

AU - Woltjer, Randall (Randy)

AU - Verástegui, Manuela R.

AU - Gilman, Robert H.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of Taenia solium and is the leading cause of preventable epilepsy worldwide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and as a cause of brain injury, but has not been well described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution toward understanding the pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelminthic treatment.

AB - Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of Taenia solium and is the leading cause of preventable epilepsy worldwide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and as a cause of brain injury, but has not been well described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution toward understanding the pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelminthic treatment.

KW - APP

KW - neurocysticercosis

KW - neurofilament

KW - spheroids

KW - T. solium oncospheres

UR - http://www.scopus.com/inward/record.url?scp=85058244121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058244121&partnerID=8YFLogxK

U2 - 10.1111/bpa.12669

DO - 10.1111/bpa.12669

M3 - Article

C2 - 30368965

AN - SCOPUS:85058244121

JO - Brain Pathology

JF - Brain Pathology

SN - 1015-6305

ER -