Axial bone mass in older women

Eric Orwoll, Douglas C. Bauer, Thomas M. Vogt, Kathleen M. Fox

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Objective: To determine the anthropometric, historical, and lifestyle factors associated with bone mineral density (BMD) of the spine and proximal femur in older women. Design: Cross-sectional analyses. Setting: Four clinical centers in Baltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela Valley, Pennsylvania. Participants: 7963 ambulatory, nonblack women 65 years of age or older. Measurements: Medical history was obtained by questionnaire and interview, and physical and anthropometric data were obtained by examination. Lumbar spine and proximal femoral BMDs were measured using dual-energy x-ray absorptiometry. Results: The multivariable models could predict 21% and 25% of the difference between participants in BMD at the femoral neck and lumbar spine, respectively. Weight was most highly associated with BMD. Postmenopausal estrogen use and other indicators of total estrogen exposure were strongly associated with increased BMD. Use of diuretics (both thiazide and nonthiazide), activity levels and muscle strength, alcohol intake, and dietary calcium intake were associated with higher BMD. A family history of osteoporotic fracture was strongly associated with low BMD. European ancestry and blond hair, childbirth or breast feeding, a history of hyperthyroidism, and progestin use were not associated with axial BMD. Conclusions: Weight is strongly associated with BMD. Estrogen exposure, physical activity, and calcium intake are also positively associated with BMD, whereas a family history of osteoporosis is associated with reduced BMD. These associations suggest ways to better identify risk for fracture.

Original languageEnglish (US)
Pages (from-to)187-196
Number of pages10
JournalAnnals of Internal Medicine
Volume124
Issue number2
StatePublished - Jan 15 1996
Externally publishedYes

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Bone Density
Bone and Bones
Estrogens
Spine
Sodium Chloride Symporter Inhibitors
Weights and Measures
Dietary Calcium
Baltimore
Osteoporotic Fractures
Femur Neck
Muscle Strength
Progestins
Hyperthyroidism
Thigh
Breast Feeding
Femur
Hair
Osteoporosis
Life Style
Cross-Sectional Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orwoll, E., Bauer, D. C., Vogt, T. M., & Fox, K. M. (1996). Axial bone mass in older women. Annals of Internal Medicine, 124(2), 187-196.

Axial bone mass in older women. / Orwoll, Eric; Bauer, Douglas C.; Vogt, Thomas M.; Fox, Kathleen M.

In: Annals of Internal Medicine, Vol. 124, No. 2, 15.01.1996, p. 187-196.

Research output: Contribution to journalArticle

Orwoll, E, Bauer, DC, Vogt, TM & Fox, KM 1996, 'Axial bone mass in older women', Annals of Internal Medicine, vol. 124, no. 2, pp. 187-196.
Orwoll E, Bauer DC, Vogt TM, Fox KM. Axial bone mass in older women. Annals of Internal Medicine. 1996 Jan 15;124(2):187-196.
Orwoll, Eric ; Bauer, Douglas C. ; Vogt, Thomas M. ; Fox, Kathleen M. / Axial bone mass in older women. In: Annals of Internal Medicine. 1996 ; Vol. 124, No. 2. pp. 187-196.
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