Avoiding immunity and apoptosis: Manipulation of the host environment by herpes simplex virus and Epstein-Barr virus

Ann B. Hill, Maria G. Masucci

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Herpesviruses infect their hosts in early life to establish latent or persistent infection with little damage to the host. They are able to reactivate throughout the life of the host and replicate to produce an infective innoculum in the face of a fully primed immune system. They achieve this lifestyle by careful manipulation of the host environment. Here we review two aspects of host defense - apoptosis of infected cells and cytotoxic T cell recognition of infected cells. We discuss avoidance of these host responses by an α-herpesvirus, herpes simplex virus, and a γ-herpesvirus, Epstein-Barr virus.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalSeminars in Virology
Volume8
Issue number5
DOIs
StatePublished - Apr 1998

ASJC Scopus subject areas

  • Immunology
  • Virology

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