Abstract
We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for 'avian') oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of vital Qin; and (iv) eight cell-coded amino acids which link the cellular Qin coding domain to the viral Gag domain. We have also characterized the expression pattern of c-qin in chicken embryos by in situ hybridization and by Northern blot analysis. c-qin is abundantly expressed in the developing brain, and this expression is restricted to the telencephalon of early embryos.
Original language | English (US) |
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Pages (from-to) | 447-451 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 92 |
Issue number | 2 |
DOIs | |
State | Published - Jan 17 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- General