Avian cellular homolog of the qin oncogene

Hwai Wen Chang, Jian Li, Doris Kretzschmar, Peter K. Vogt

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for 'avian') oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of vital Qin; and (iv) eight cell-coded amino acids which link the cellular Qin coding domain to the viral Gag domain. We have also characterized the expression pattern of c-qin in chicken embryos by in situ hybridization and by Northern blot analysis. c-qin is abundantly expressed in the developing brain, and this expression is restricted to the telencephalon of early embryos.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number2
DOIs
StatePublished - Jan 17 1995
Externally publishedYes

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Oncogenes
Chickens
Embryonic Structures
Avian Sarcoma Viruses
Telencephalon
Nonsense Codon
Viral Proteins
Amino Acid Substitution
Northern Blotting
In Situ Hybridization
Complementary DNA
Clone Cells
Amino Acids
Brain
Genes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Avian cellular homolog of the qin oncogene. / Chang, Hwai Wen; Li, Jian; Kretzschmar, Doris; Vogt, Peter K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 2, 17.01.1995, p. 447-451.

Research output: Contribution to journalArticle

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