Avascular necrosis of bone after allogeneic hematopoietic cell transplantation in children and adolescents

Xiaxin Li, Ruta Brazauskas, Zhiwei Wang, Amal Al-Seraihy, K. Scott Baker, Jean Yves Cahn, Haydar A. Frangoul, James L. Gajewski, Gregory A. Hale, Jack W. Hsu, Rammurti T. Kamble, Hillard M. Lazarus, David I. Marks, Richard Maziarz, Bipin N. Savani, Ami J. Shah, Nirali Shah, Mohamed L. Sorror, William A. Wood, Navneet S. Majhail

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We conducted a nested case-control study within a cohort of 6244 patients to assess risk factors for avascular necrosis (AVN) of bone in children and adolescents after allogeneic transplantation. Eligible patients were ≤21years of age, received their first allogeneic transplant between 1990 and 2008 in the United States, and had survived ≥ 6months from transplantation. Overall, 160 patients with AVN and 478 control subjects matched by year of transplant, length of follow-up and transplant center were identified. Patients and control subjects were confirmed via central review of radiology, pathology, and/or surgical procedure reports. Median time from transplant to diagnosis of AVN was 14months. On conditional logistic regression, increasing age at transplant (≥5years), female gender, and chronic graft-versus-host disease (GVHD) were significantly associated with increased risks of AVN. Compared with patients receiving myeloablative regimens for malignant diseases, lower risks of AVN were seen in patients with nonmalignant diseases and those who had received reduced-intensity conditioning regimens for malignant diseases. Children at high risk for AVN include those within the age group where rapid bone growth occurs as well as those who experience exposure to myeloablative conditioning regimens and immunosuppression after hematopoietic cell transplantation for the treatment of GVHD. More research is needed to determine whether screening strategies specifically for patients at high risk for developing AVN with early interventions may mitigate the morbidity associated with this complication.

Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Osteonecrosis
Cell Transplantation
Necrosis
Transplants
Graft vs Host Disease
Surgical Pathology
Bone Development
Homologous Transplantation
Radiology
Immunosuppression
Case-Control Studies
Age Groups
Transplantation
Logistic Models
Morbidity
Research

Keywords

  • Avascular necrosis
  • Hematopoietic cell transplantation
  • Late complications

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Avascular necrosis of bone after allogeneic hematopoietic cell transplantation in children and adolescents. / Li, Xiaxin; Brazauskas, Ruta; Wang, Zhiwei; Al-Seraihy, Amal; Baker, K. Scott; Cahn, Jean Yves; Frangoul, Haydar A.; Gajewski, James L.; Hale, Gregory A.; Hsu, Jack W.; Kamble, Rammurti T.; Lazarus, Hillard M.; Marks, David I.; Maziarz, Richard; Savani, Bipin N.; Shah, Ami J.; Shah, Nirali; Sorror, Mohamed L.; Wood, William A.; Majhail, Navneet S.

In: Biology of Blood and Marrow Transplantation, Vol. 20, No. 4, 2014, p. 587-592.

Research output: Contribution to journalArticle

Li, X, Brazauskas, R, Wang, Z, Al-Seraihy, A, Baker, KS, Cahn, JY, Frangoul, HA, Gajewski, JL, Hale, GA, Hsu, JW, Kamble, RT, Lazarus, HM, Marks, DI, Maziarz, R, Savani, BN, Shah, AJ, Shah, N, Sorror, ML, Wood, WA & Majhail, NS 2014, 'Avascular necrosis of bone after allogeneic hematopoietic cell transplantation in children and adolescents', Biology of Blood and Marrow Transplantation, vol. 20, no. 4, pp. 587-592. https://doi.org/10.1016/j.bbmt.2013.12.567
Li, Xiaxin ; Brazauskas, Ruta ; Wang, Zhiwei ; Al-Seraihy, Amal ; Baker, K. Scott ; Cahn, Jean Yves ; Frangoul, Haydar A. ; Gajewski, James L. ; Hale, Gregory A. ; Hsu, Jack W. ; Kamble, Rammurti T. ; Lazarus, Hillard M. ; Marks, David I. ; Maziarz, Richard ; Savani, Bipin N. ; Shah, Ami J. ; Shah, Nirali ; Sorror, Mohamed L. ; Wood, William A. ; Majhail, Navneet S. / Avascular necrosis of bone after allogeneic hematopoietic cell transplantation in children and adolescents. In: Biology of Blood and Marrow Transplantation. 2014 ; Vol. 20, No. 4. pp. 587-592.
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AU - Li, Xiaxin

AU - Brazauskas, Ruta

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AU - Al-Seraihy, Amal

AU - Baker, K. Scott

AU - Cahn, Jean Yves

AU - Frangoul, Haydar A.

AU - Gajewski, James L.

AU - Hale, Gregory A.

AU - Hsu, Jack W.

AU - Kamble, Rammurti T.

AU - Lazarus, Hillard M.

AU - Marks, David I.

AU - Maziarz, Richard

AU - Savani, Bipin N.

AU - Shah, Ami J.

AU - Shah, Nirali

AU - Sorror, Mohamed L.

AU - Wood, William A.

AU - Majhail, Navneet S.

PY - 2014

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