Autosomal Dominant Acute Necrotizing Encephalopathy Maps to 2q12.1-2q13

Derek E. Neilson; Heidi S. Feiler; Kirk C. Wilhelmsen; Audrey Lynn; Robert M. Eiben; Douglas S. Kerr; Matthew L. Warman

doi:10.1002/ana.10849

Autosomal Dominant Acute Necrotizing Encephalopathy Maps to 2q12.1-2q13

Derek E. Neilson, Heidi S. Feiler, Kirk C. Wilhelmsen, Audrey Lynn, Robert M. Eiben, Douglas S. Kerr, Matthew L. Warman

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In autosomal dominant acute necrotizing encephalopathy (ADANE), apparently healthy children develop necrotizing lesions in their thalami and brainstems in the course of febrile illnesses. We used DNA from affected subjects and obligate carriers to map ADANE to a 6.5Mb region on chromosome 2. Sequencing of four candidate genes in the interval (BCL2L11, ST6GalII, CHT1, and FLJ20019), involved in apoptosis, viral recognition, choline transport, and electron transport, showed no disease causing mutations.

Original language	English (US)
Pages (from-to)	291-294
Number of pages	4
Journal	Annals of Neurology
Volume	55
Issue number	2
DOIs	https://doi.org/10.1002/ana.10849
State	Published - Feb 2004
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Autosomal Dominant Acute Necrotizing Encephalopathy Maps to 2q12.1-2q13",

abstract = "In autosomal dominant acute necrotizing encephalopathy (ADANE), apparently healthy children develop necrotizing lesions in their thalami and brainstems in the course of febrile illnesses. We used DNA from affected subjects and obligate carriers to map ADANE to a 6.5Mb region on chromosome 2. Sequencing of four candidate genes in the interval (BCL2L11, ST6GalII, CHT1, and FLJ20019), involved in apoptosis, viral recognition, choline transport, and electron transport, showed no disease causing mutations.",

author = "Neilson, {Derek E.} and Feiler, {Heidi S.} and Wilhelmsen, {Kirk C.} and Audrey Lynn and Eiben, {Robert M.} and Kerr, {Douglas S.} and Warman, {Matthew L.}",

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AU - Neilson, Derek E.

AU - Feiler, Heidi S.

AU - Wilhelmsen, Kirk C.

AU - Lynn, Audrey

AU - Eiben, Robert M.

AU - Kerr, Douglas S.

AU - Warman, Matthew L.

PY - 2004/2

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AB - In autosomal dominant acute necrotizing encephalopathy (ADANE), apparently healthy children develop necrotizing lesions in their thalami and brainstems in the course of febrile illnesses. We used DNA from affected subjects and obligate carriers to map ADANE to a 6.5Mb region on chromosome 2. Sequencing of four candidate genes in the interval (BCL2L11, ST6GalII, CHT1, and FLJ20019), involved in apoptosis, viral recognition, choline transport, and electron transport, showed no disease causing mutations.

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Autosomal Dominant Acute Necrotizing Encephalopathy Maps to 2q12.1-2q13

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