Autophagy and fetal programming

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Accumulated epidemiological and experimental evidence established a link between in utero environment, and a high propensity for cardiovascular and metabolic disorders in adult life, so-called fetal programming phenomenon whereby a long-term and irreversible alteration in structure or metabolism is induced by a relatively brief exposure to adverse conditions during gestation. A range of gestational events can change the fetal development: maternal over- and undernutrition, gestational diabetes, exposure to environmental toxins, maternal and paternal lifestyle choices, and social and psychological stresses. Many of these events can be influenced by autophagy, an evolutionarily conserved form of adaptation to adverse conditions. Here, we discuss the regulation of autophagy under normal intrauterine conditions, as well as its alterations as a result of fetal programming.

Original languageEnglish (US)
Title of host publicationAutophagy and Cardiometabolic Diseases
Subtitle of host publicationFrom Molecular Mechanisms to Translational Medicine
PublisherElsevier
Pages225-235
Number of pages11
ISBN (Electronic)9780128052532
ISBN (Print)9780128054420
DOIs
StatePublished - Jan 1 2018

Keywords

  • Defective autophagy
  • Fetal or developmental programming
  • Gestational diabetes
  • Maternal obesity
  • Maternal undernutrition
  • Placenta
  • Preeclampsia

ASJC Scopus subject areas

  • Medicine(all)

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