Autonomic tone in patients with supraventricular arrhythmia associated with mitral valve prolapse in young men

Larissa Terechtchenko, Svetlana A. Doronina, Elena M. Pochinok, Alexander Riftine

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    This study examined the relation between autonomic tone and the frequency and duration of supraventricular arrhythmias (SVA) in 44 men (mean age 17 ± 5 years) with mitral valve prolapse (MVP), confirmed by echocardiography. Ambulatory and short-term electrocardiograms (ECG) were recorded, and transesophageal pacing was performed. Frequency domain heart rate variability (HRV) indices were obtained from short-term ECG recordings at rest and during postural stress. Results: In 14 patients, the index of parasympathetic activity was significantly higher (2.1 ± 0, 01 vs -1.5 ± 0.01, P < 0.01), and associated with a high incidence of vagally-mediated SVA. The frequency of SV premature beats in patients with parasympathetic prevalence was 58 ± 86/hour versus 10 ± 27/hour in patients with sympathetic prevalence (P ± 0.05). In 30 patients with high sympathetic activity, the index of sympathetic tone was significantly higher (3.1±0.01 vs 0.5±0.01) and the high frequency/low frequency ratio significantly lower (0.294 ± 0.03 vs 0.581 ± 0.02, P < 0.05), though the incidence of SVA was significantly lower and duration shorter. The algorithm allowed the noninvasive quantitative assessment of autonomic activity and mechanism behind the development of SVA, which may help in the choice of treatment.

    Original languageEnglish (US)
    Pages (from-to)444-446
    Number of pages3
    JournalPACE - Pacing and Clinical Electrophysiology
    Volume26
    Issue number1 II
    StatePublished - Jan 1 2003

    Keywords

    • Heart rate variability
    • Mitral valve prolapse
    • Supraventricular arrhythmia

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Fingerprint Dive into the research topics of 'Autonomic tone in patients with supraventricular arrhythmia associated with mitral valve prolapse in young men'. Together they form a unique fingerprint.

  • Cite this