Autonomic dysfunction syndromes after acute brain injury

Courtney Takahashi, Holly Hinson, Ian J. Baguley

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The central autonomic nervous system (CAN) is a multifaceted, richly connected neural network incorporating the hypothalamus, its descending tracts through the brainstem, the insular cortex and down into the spinal cord. All levels of the CAN are susceptible to injury following traumatic brain injury (TBI), whether from focal or diffuse injury. Focal injuries would be expected to produce localized damage to CAN control centers, whereas the effects of diffuse injuries are presumed to be more diverse and/or widely distributed.As the combination of focal and diffuse injury following TBI can vary widely from one individual to the next, the impact of focal injuries is best understood with reference to the focal ischemic stroke literature. Subarachnoid hemorrhage (SAH), a common complication following TBI, also has predictable effects on autonomic control that can be understood with reference to spontaneous SAH literature. Finally, paroxysmal sympathetic hyperactivity (PSH), a syndrome incorporating episodes of heightened sympathetic drive and motor overactivity following minor stimulation, is discussed as an example of what happens when central inhibitory control of spinal cord autonomics is impaired.

Original languageEnglish (US)
Pages (from-to)539-551
Number of pages13
JournalHandbook of Clinical Neurology
Volume128
DOIs
StatePublished - 2015

Fingerprint

Brain Injuries
Autonomic Nervous System
Wounds and Injuries
Central Nervous System
Subarachnoid Hemorrhage
Spinal Cord
Cerebral Cortex
Hypothalamus
Brain Stem
Stroke
Traumatic Brain Injury

Keywords

  • Central autonomic network
  • Hyperadrenergic crisis
  • Paroxysmal sympathetic hyperactivity
  • Stroke
  • Subarachnoid hemorrhage
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Autonomic dysfunction syndromes after acute brain injury. / Takahashi, Courtney; Hinson, Holly; Baguley, Ian J.

In: Handbook of Clinical Neurology, Vol. 128, 2015, p. 539-551.

Research output: Contribution to journalArticle

Takahashi, Courtney ; Hinson, Holly ; Baguley, Ian J. / Autonomic dysfunction syndromes after acute brain injury. In: Handbook of Clinical Neurology. 2015 ; Vol. 128. pp. 539-551.
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