Autonomic dysfunction syndromes after acute brain injury

Courtney Takahashi, Holly E. Hinson, Ian J. Baguley

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

The central autonomic nervous system (CAN) is a multifaceted, richly connected neural network incorporating the hypothalamus, its descending tracts through the brainstem, the insular cortex and down into the spinal cord. All levels of the CAN are susceptible to injury following traumatic brain injury (TBI), whether from focal or diffuse injury. Focal injuries would be expected to produce localized damage to CAN control centers, whereas the effects of diffuse injuries are presumed to be more diverse and/or widely distributed.As the combination of focal and diffuse injury following TBI can vary widely from one individual to the next, the impact of focal injuries is best understood with reference to the focal ischemic stroke literature. Subarachnoid hemorrhage (SAH), a common complication following TBI, also has predictable effects on autonomic control that can be understood with reference to spontaneous SAH literature. Finally, paroxysmal sympathetic hyperactivity (PSH), a syndrome incorporating episodes of heightened sympathetic drive and motor overactivity following minor stimulation, is discussed as an example of what happens when central inhibitory control of spinal cord autonomics is impaired.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages539-551
Number of pages13
DOIs
StatePublished - Jan 1 2015

Publication series

NameHandbook of Clinical Neurology
Volume128
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

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Keywords

  • Central autonomic network
  • Hyperadrenergic crisis
  • Paroxysmal sympathetic hyperactivity
  • Stroke
  • Subarachnoid hemorrhage
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Takahashi, C., Hinson, H. E., & Baguley, I. J. (2015). Autonomic dysfunction syndromes after acute brain injury. In Handbook of Clinical Neurology (pp. 539-551). (Handbook of Clinical Neurology; Vol. 128). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-63521-1.00034-0