Autonomic dysfunction in Parkinson's disease: A comprehensive symptom survey

M. F. Siddiqui, S. Rast, M. J. Lynn, A. P. Auchus, R. F. Pfeiffer

Research output: Contribution to journalArticlepeer-review

164 Scopus citations


Background: Autonomic dysfunction occurs in Parkinson's disease (PD), but few studies have addressed it in a comprehensive manner. Methods: Autonomic symptoms were evaluated by a questionnaire in sixty-eight subjects (44 patients and 24 controls). Results: PD patients experienced higher frequency and severity of autonomic dysfunction. When all autonomic symptoms were pooled into an aggregate score, differences between patients and controls were highly statistically significant (p < 0.0001). 'Increased salivation', 'frequency of dysphagia', decreased 'BM (bowel movement) frequency', i.e. constipation, and 'orthostatic dizziness' were more frequent in PD patients (p < 0.05). A prediction model to determine the predictors of autonomic dysfunction was unsuccessful. Conclusion: Differences in the prevalence of autonomic symptoms in PD and non-parkinsonian controls are apparent from this study.

Original languageEnglish (US)
Pages (from-to)277-284
Number of pages8
JournalParkinsonism and Related Disorders
Issue number4
StatePublished - 2002


  • Autonomic function
  • Multiple system atrophy
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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