Autonomic Control During Pregnancy

Virginia Brooks, Belinda McCully, Priscila A. Cassaglia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter discusses how pregnancy activates the sympathetic nervous system and pregnancy impairs the baroreceptor reflex. In parallel to increases in fluid-retaining hormones, alterations in the autonomic nervous system accompany normal pregnancy. While pregnancy induces sympathoexcitation, simultaneously, basal parasympathetic tone decreases. Baroreflex dysfunction has been documented in several species besides humans, including rabbits, rats, goats, sheep, and dogs. While pregnancy could depress the function of any or all anatomical links within the baroreflex pathway, current evidence indicates that brain control is particularly impaired. Insulin resistance is a normal adaption of pregnancy that, by increasing circulating glucose levels, serves to enhance glucose availability into the fetus. Preeclampsia is a potentially fatal hypertensive disorder of pregnancy that is initiated by reduced placental perfusion. Increased sympathetic tone may contribute to the hypertension, since basal muscle sympathetic nerve activity is clearly increased above the levels observed in normal pregnant women. The changes in basal autonomic tone may counteract to some degree the profound vasodilation that is a hallmark of normal pregnancy.

Original languageEnglish (US)
Title of host publicationPrimer on the Autonomic Nervous System
PublisherElsevier Inc.
Pages265-268
Number of pages4
ISBN (Print)9780123865250
DOIs
StatePublished - 2012

Fingerprint

Pregnancy
Baroreflex
Glucose
Autonomic Nervous System
Sympathetic Nervous System
Pre-Eclampsia
Goats
Vasodilation
Insulin Resistance
Pregnant Women
Sheep
Fetus
Perfusion
Hormones
Dogs
Rabbits
Hypertension
Muscles
Brain

Keywords

  • 3α-hydroxy-dihydroprogesterone
  • Arcuate nucleus
  • Baroreceptor reflex
  • Heart rate
  • Insulin
  • Parasympathetic nerve activity
  • Pregnancy
  • Rostral ventrolateral medulla
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brooks, V., McCully, B., & Cassaglia, P. A. (2012). Autonomic Control During Pregnancy. In Primer on the Autonomic Nervous System (pp. 265-268). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386525-0.00055-X

Autonomic Control During Pregnancy. / Brooks, Virginia; McCully, Belinda; Cassaglia, Priscila A.

Primer on the Autonomic Nervous System. Elsevier Inc., 2012. p. 265-268.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brooks, V, McCully, B & Cassaglia, PA 2012, Autonomic Control During Pregnancy. in Primer on the Autonomic Nervous System. Elsevier Inc., pp. 265-268. https://doi.org/10.1016/B978-0-12-386525-0.00055-X
Brooks V, McCully B, Cassaglia PA. Autonomic Control During Pregnancy. In Primer on the Autonomic Nervous System. Elsevier Inc. 2012. p. 265-268 https://doi.org/10.1016/B978-0-12-386525-0.00055-X
Brooks, Virginia ; McCully, Belinda ; Cassaglia, Priscila A. / Autonomic Control During Pregnancy. Primer on the Autonomic Nervous System. Elsevier Inc., 2012. pp. 265-268
@inbook{45dfa35be5a548fa845f769eb5599dbd,
title = "Autonomic Control During Pregnancy",
abstract = "This chapter discusses how pregnancy activates the sympathetic nervous system and pregnancy impairs the baroreceptor reflex. In parallel to increases in fluid-retaining hormones, alterations in the autonomic nervous system accompany normal pregnancy. While pregnancy induces sympathoexcitation, simultaneously, basal parasympathetic tone decreases. Baroreflex dysfunction has been documented in several species besides humans, including rabbits, rats, goats, sheep, and dogs. While pregnancy could depress the function of any or all anatomical links within the baroreflex pathway, current evidence indicates that brain control is particularly impaired. Insulin resistance is a normal adaption of pregnancy that, by increasing circulating glucose levels, serves to enhance glucose availability into the fetus. Preeclampsia is a potentially fatal hypertensive disorder of pregnancy that is initiated by reduced placental perfusion. Increased sympathetic tone may contribute to the hypertension, since basal muscle sympathetic nerve activity is clearly increased above the levels observed in normal pregnant women. The changes in basal autonomic tone may counteract to some degree the profound vasodilation that is a hallmark of normal pregnancy.",
keywords = "3α-hydroxy-dihydroprogesterone, Arcuate nucleus, Baroreceptor reflex, Heart rate, Insulin, Parasympathetic nerve activity, Pregnancy, Rostral ventrolateral medulla, Sympathetic nerve activity",
author = "Virginia Brooks and Belinda McCully and Cassaglia, {Priscila A.}",
year = "2012",
doi = "10.1016/B978-0-12-386525-0.00055-X",
language = "English (US)",
isbn = "9780123865250",
pages = "265--268",
booktitle = "Primer on the Autonomic Nervous System",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Autonomic Control During Pregnancy

AU - Brooks, Virginia

AU - McCully, Belinda

AU - Cassaglia, Priscila A.

PY - 2012

Y1 - 2012

N2 - This chapter discusses how pregnancy activates the sympathetic nervous system and pregnancy impairs the baroreceptor reflex. In parallel to increases in fluid-retaining hormones, alterations in the autonomic nervous system accompany normal pregnancy. While pregnancy induces sympathoexcitation, simultaneously, basal parasympathetic tone decreases. Baroreflex dysfunction has been documented in several species besides humans, including rabbits, rats, goats, sheep, and dogs. While pregnancy could depress the function of any or all anatomical links within the baroreflex pathway, current evidence indicates that brain control is particularly impaired. Insulin resistance is a normal adaption of pregnancy that, by increasing circulating glucose levels, serves to enhance glucose availability into the fetus. Preeclampsia is a potentially fatal hypertensive disorder of pregnancy that is initiated by reduced placental perfusion. Increased sympathetic tone may contribute to the hypertension, since basal muscle sympathetic nerve activity is clearly increased above the levels observed in normal pregnant women. The changes in basal autonomic tone may counteract to some degree the profound vasodilation that is a hallmark of normal pregnancy.

AB - This chapter discusses how pregnancy activates the sympathetic nervous system and pregnancy impairs the baroreceptor reflex. In parallel to increases in fluid-retaining hormones, alterations in the autonomic nervous system accompany normal pregnancy. While pregnancy induces sympathoexcitation, simultaneously, basal parasympathetic tone decreases. Baroreflex dysfunction has been documented in several species besides humans, including rabbits, rats, goats, sheep, and dogs. While pregnancy could depress the function of any or all anatomical links within the baroreflex pathway, current evidence indicates that brain control is particularly impaired. Insulin resistance is a normal adaption of pregnancy that, by increasing circulating glucose levels, serves to enhance glucose availability into the fetus. Preeclampsia is a potentially fatal hypertensive disorder of pregnancy that is initiated by reduced placental perfusion. Increased sympathetic tone may contribute to the hypertension, since basal muscle sympathetic nerve activity is clearly increased above the levels observed in normal pregnant women. The changes in basal autonomic tone may counteract to some degree the profound vasodilation that is a hallmark of normal pregnancy.

KW - 3α-hydroxy-dihydroprogesterone

KW - Arcuate nucleus

KW - Baroreceptor reflex

KW - Heart rate

KW - Insulin

KW - Parasympathetic nerve activity

KW - Pregnancy

KW - Rostral ventrolateral medulla

KW - Sympathetic nerve activity

UR - http://www.scopus.com/inward/record.url?scp=84882887514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882887514&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-386525-0.00055-X

DO - 10.1016/B978-0-12-386525-0.00055-X

M3 - Chapter

SN - 9780123865250

SP - 265

EP - 268

BT - Primer on the Autonomic Nervous System

PB - Elsevier Inc.

ER -