Autonomic and arginine vasopressin modulation of the hypoxia-induced atrial natriuretic factor release in immature and mature ovine fetuses

Cecilia Cheung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: This study investigated the maturational change in the atrial natriuretic factor response to hypoxia in ovine fetuses and the role of the autonomic nervous system and arginine vasopressin in modulating this response. Study design: Chronically catheterized ovine fetuses from 110 to 135 days' gestation were subjected to 30 minutes of hypoxia. The fetuses were either intact, treated with hexamethonium to block the autonomic nervous system, or treated with a pressor antagonist of arginine vasopressin. Results: Hypoxia elevated plasma atrial natriuretic factor levels by 1635 ± 265 pg/ml in immature fetuses; this response was greater than the increase of 748 ± 189 pg/ml in mature fetuses (p <0.0001). Blockade of the autonomic nervous system reduced the atrial natriuretic factor response and suppressed the vascular pressure changes to hypoxia in immature but not in mature fetuses. A vasopressin pressor antagonist suppressed the atrial natriuretic factor but not vascular pressure responses to hypoxia in mature fetuses. Conclusions: This study demonstrates that the immature fetus manifested a greater atrial natriuretic factor response to hypoxia than did the mature fetus. This enhanced response appeared to be dependent on the modulatory effects of the autonomic nervous system on vascular pressures during hypoxia. In addition, arginine vasopressin appeared to augment the atrial natriuretic factor response to hypoxia in the mature fetus independent of vascular pressure changes.

Original languageEnglish (US)
Pages (from-to)1443-1453
Number of pages11
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number5
StatePublished - 1992
Externally publishedYes

Fingerprint

Arginine Vasopressin
Atrial Natriuretic Factor
Sheep
Fetus
Autonomic Nervous System
Blood Vessels
Pressure
Hypoxia
Hexamethonium
Pregnancy

Keywords

  • arginine vasopressin
  • atrial natriuretic factor
  • autonomic nervous system
  • fetal development
  • reduced oxygen tension

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

@article{5b7a8371defc433295d20e18edb878bb,
title = "Autonomic and arginine vasopressin modulation of the hypoxia-induced atrial natriuretic factor release in immature and mature ovine fetuses",
abstract = "Objective: This study investigated the maturational change in the atrial natriuretic factor response to hypoxia in ovine fetuses and the role of the autonomic nervous system and arginine vasopressin in modulating this response. Study design: Chronically catheterized ovine fetuses from 110 to 135 days' gestation were subjected to 30 minutes of hypoxia. The fetuses were either intact, treated with hexamethonium to block the autonomic nervous system, or treated with a pressor antagonist of arginine vasopressin. Results: Hypoxia elevated plasma atrial natriuretic factor levels by 1635 ± 265 pg/ml in immature fetuses; this response was greater than the increase of 748 ± 189 pg/ml in mature fetuses (p <0.0001). Blockade of the autonomic nervous system reduced the atrial natriuretic factor response and suppressed the vascular pressure changes to hypoxia in immature but not in mature fetuses. A vasopressin pressor antagonist suppressed the atrial natriuretic factor but not vascular pressure responses to hypoxia in mature fetuses. Conclusions: This study demonstrates that the immature fetus manifested a greater atrial natriuretic factor response to hypoxia than did the mature fetus. This enhanced response appeared to be dependent on the modulatory effects of the autonomic nervous system on vascular pressures during hypoxia. In addition, arginine vasopressin appeared to augment the atrial natriuretic factor response to hypoxia in the mature fetus independent of vascular pressure changes.",
keywords = "arginine vasopressin, atrial natriuretic factor, autonomic nervous system, fetal development, reduced oxygen tension",
author = "Cecilia Cheung",
year = "1992",
language = "English (US)",
volume = "167",
pages = "1443--1453",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Autonomic and arginine vasopressin modulation of the hypoxia-induced atrial natriuretic factor release in immature and mature ovine fetuses

AU - Cheung, Cecilia

PY - 1992

Y1 - 1992

N2 - Objective: This study investigated the maturational change in the atrial natriuretic factor response to hypoxia in ovine fetuses and the role of the autonomic nervous system and arginine vasopressin in modulating this response. Study design: Chronically catheterized ovine fetuses from 110 to 135 days' gestation were subjected to 30 minutes of hypoxia. The fetuses were either intact, treated with hexamethonium to block the autonomic nervous system, or treated with a pressor antagonist of arginine vasopressin. Results: Hypoxia elevated plasma atrial natriuretic factor levels by 1635 ± 265 pg/ml in immature fetuses; this response was greater than the increase of 748 ± 189 pg/ml in mature fetuses (p <0.0001). Blockade of the autonomic nervous system reduced the atrial natriuretic factor response and suppressed the vascular pressure changes to hypoxia in immature but not in mature fetuses. A vasopressin pressor antagonist suppressed the atrial natriuretic factor but not vascular pressure responses to hypoxia in mature fetuses. Conclusions: This study demonstrates that the immature fetus manifested a greater atrial natriuretic factor response to hypoxia than did the mature fetus. This enhanced response appeared to be dependent on the modulatory effects of the autonomic nervous system on vascular pressures during hypoxia. In addition, arginine vasopressin appeared to augment the atrial natriuretic factor response to hypoxia in the mature fetus independent of vascular pressure changes.

AB - Objective: This study investigated the maturational change in the atrial natriuretic factor response to hypoxia in ovine fetuses and the role of the autonomic nervous system and arginine vasopressin in modulating this response. Study design: Chronically catheterized ovine fetuses from 110 to 135 days' gestation were subjected to 30 minutes of hypoxia. The fetuses were either intact, treated with hexamethonium to block the autonomic nervous system, or treated with a pressor antagonist of arginine vasopressin. Results: Hypoxia elevated plasma atrial natriuretic factor levels by 1635 ± 265 pg/ml in immature fetuses; this response was greater than the increase of 748 ± 189 pg/ml in mature fetuses (p <0.0001). Blockade of the autonomic nervous system reduced the atrial natriuretic factor response and suppressed the vascular pressure changes to hypoxia in immature but not in mature fetuses. A vasopressin pressor antagonist suppressed the atrial natriuretic factor but not vascular pressure responses to hypoxia in mature fetuses. Conclusions: This study demonstrates that the immature fetus manifested a greater atrial natriuretic factor response to hypoxia than did the mature fetus. This enhanced response appeared to be dependent on the modulatory effects of the autonomic nervous system on vascular pressures during hypoxia. In addition, arginine vasopressin appeared to augment the atrial natriuretic factor response to hypoxia in the mature fetus independent of vascular pressure changes.

KW - arginine vasopressin

KW - atrial natriuretic factor

KW - autonomic nervous system

KW - fetal development

KW - reduced oxygen tension

UR - http://www.scopus.com/inward/record.url?scp=0026464002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026464002&partnerID=8YFLogxK

M3 - Article

C2 - 1443003

AN - SCOPUS:0026464002

VL - 167

SP - 1443

EP - 1453

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -