Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm

Michelle Cua, Xiyun Liu, Dongkai Miao, Sujin Lee, Sieun Lee, Stefano Bonora, Robert J. Zawadzki, Paul J. Mackenzie, Yifan Jian, Marinko V. Sarunic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXV
EditorsArthur Ho, Fabrice Manns, Per G. Soderberg
PublisherSPIE
ISBN (Electronic)9781628413977
DOIs
StatePublished - Jan 1 2015
Externally publishedYes
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9307
ISSN (Print)1605-7422

Conference

Conference25th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Fingerprint

Optical tomography
Optical Coherence Tomography
tomography
high speed
Imaging techniques
optimization
high resolution
Optical resolving power
Social Adjustment
Nerve Fibers
Visualization
Lenses
nerve fibers
pathogenesis
Research Personnel
Medical imaging
Image resolution
adjusting
lenses
Fibers

Keywords

  • en face OCT
  • focus stacking
  • GPU acceleration
  • high-resolution OCT
  • variable focus lens

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Cua, M., Liu, X., Miao, D., Lee, S., Lee, S., Bonora, S., ... Sarunic, M. V. (2015). Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. In A. Ho, F. Manns, & P. G. Soderberg (Eds.), Ophthalmic Technologies XXV [93071D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9307). SPIE. https://doi.org/10.1117/12.2079665

Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. / Cua, Michelle; Liu, Xiyun; Miao, Dongkai; Lee, Sujin; Lee, Sieun; Bonora, Stefano; Zawadzki, Robert J.; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

Ophthalmic Technologies XXV. ed. / Arthur Ho; Fabrice Manns; Per G. Soderberg. SPIE, 2015. 93071D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9307).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cua, M, Liu, X, Miao, D, Lee, S, Lee, S, Bonora, S, Zawadzki, RJ, Mackenzie, PJ, Jian, Y & Sarunic, MV 2015, Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. in A Ho, F Manns & PG Soderberg (eds), Ophthalmic Technologies XXV., 93071D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9307, SPIE, 25th Conference on Ophthalmic Technologies, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2079665
Cua M, Liu X, Miao D, Lee S, Lee S, Bonora S et al. Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. In Ho A, Manns F, Soderberg PG, editors, Ophthalmic Technologies XXV. SPIE. 2015. 93071D. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2079665
Cua, Michelle ; Liu, Xiyun ; Miao, Dongkai ; Lee, Sujin ; Lee, Sieun ; Bonora, Stefano ; Zawadzki, Robert J. ; Mackenzie, Paul J. ; Jian, Yifan ; Sarunic, Marinko V. / Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm. Ophthalmic Technologies XXV. editor / Arthur Ho ; Fabrice Manns ; Per G. Soderberg. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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