Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm

Michelle Cua, Xiyun Liu, Dongkai Miao, Sujin Lee, Sieun Lee, Stefano Bonora, Robert J. Zawadzki, Paul J. Mackenzie, Yifan Jian, Marinko V. Sarunic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-Time. A GPU-Accelerated segmentation and optimization was used to provide real-Time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXV
EditorsArthur Ho, Fabrice Manns, Per G. Soderberg
ISBN (Electronic)9781628413977
StatePublished - Jan 1 2015
Externally publishedYes
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


Conference25th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco


  • GPU acceleration
  • en face OCT
  • focus stacking
  • high-resolution OCT
  • variable focus lens

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm'. Together they form a unique fingerprint.

Cite this