Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

Pengxiao Zang, Gangjun Liu, Miao Zhang, Jie Wang, Thomas Hwang, David Wilson, David Huang, Dengwang Li, Jia Yali

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.

Original languageEnglish (US)
Article number026001
JournalJournal of Biomedical Optics
Volume22
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Image processing
  • Optical coherence tomography
  • Three-dimensional registration
  • Wide-field

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering

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