Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

Pengxiao Zang, Gangjun Liu, Miao Zhang, Jie Wang, Thomas S. Hwang, David J. Wilson, David Huang, Dengwang Li, Yali Jia

Research output: Research - peer-reviewArticle

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Abstract

We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.

LanguageEnglish (US)
Article number026001
JournalJournal of Biomedical Optics
Volume22
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

tomography
Optical tomography
angiography
Angiography
artifacts
image contrast
membranes
optimization
Membranes

Keywords

  • Image processing
  • Optical coherence tomography
  • Three-dimensional registration
  • Wide-field

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering

Cite this

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title = "Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography",
abstract = "We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.",
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author = "Pengxiao Zang and Gangjun Liu and Miao Zhang and Jie Wang and Hwang, {Thomas S.} and Wilson, {David J.} and David Huang and Dengwang Li and Yali Jia",
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AU - Liu,Gangjun

AU - Zhang,Miao

AU - Wang,Jie

AU - Hwang,Thomas S.

AU - Wilson,David J.

AU - Huang,David

AU - Li,Dengwang

AU - Jia,Yali

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