Autologous vein stent-graft: Feasibility study

Alexander Ferko, Jiří Páral, Jan Raupach, Vendelin Chovanec, Antonín Krajina, Pavel Měřička, Dusan Pavcnik, Barry Uchida, Dáša Slížová, Oto Krs, Jan Nožička

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE: To evaluate expandable stents healed into vein wall as autologous vein stent-grafts for endoluminal grafting. MATERIALS AND METHODS: Balloon expandable stents were placed into external jugular veins of eight dogs. Stent and vein patency was followed by ultrasonography. Five weeks after stent placement, jugular veins with endothelialized stent were harvested? The autologous vein stent-grafts were divided into two groups. In group A, autologous vein stent-grafts (n = 3) were placed immediately into Baker solution for microscopic examination. In group B, autologous vein stent-grafts (n = 3) underwent mechanical manipulation; they were compressed, mounted on angioplasty balloon, pushed through a 9-F sheath and dilated. The autologous vein stent-graft endothelialization and changes after mechanical manipulation were evaluated by light and electron microscopy. RESULTS: Stent placement was successful in seven dogs. One stent migrated into the pulmonary artery. One well placed stent was damaged by compression dressing and thrombosed. At 5 weeks, gross and microscopic examinations revealed the autologous vein stent-grafts were fully covered by a 0.115- ± 0.036-mm thick neointimal layer. Small wall thrombus was observed in one autologous vein stent-graft. Repeated manipulations did not result in any intimal damage or stent loosening in the autologous vein stent-grafts. CONCLUSION: Expandable stents healed into a vein have potential to be used as autologous vein stent- grafts for endoluminal grafting without risk of disruption during percutaneous transcatheter introduction.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalJournal of Vascular and Interventional Radiology
Volume11
Issue number1
StatePublished - Jan 2000

Fingerprint

Feasibility Studies
Stents
Veins
Transplants
Jugular Veins
Thrombosis
Dogs
Tunica Intima
Balloon Angioplasty
Bandages

Keywords

  • Endovascular stent grafts
  • Stents and prostheses

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ferko, A., Páral, J., Raupach, J., Chovanec, V., Krajina, A., Měřička, P., ... Nožička, J. (2000). Autologous vein stent-graft: Feasibility study. Journal of Vascular and Interventional Radiology, 11(1), 111-114.

Autologous vein stent-graft : Feasibility study. / Ferko, Alexander; Páral, Jiří; Raupach, Jan; Chovanec, Vendelin; Krajina, Antonín; Měřička, Pavel; Pavcnik, Dusan; Uchida, Barry; Slížová, Dáša; Krs, Oto; Nožička, Jan.

In: Journal of Vascular and Interventional Radiology, Vol. 11, No. 1, 01.2000, p. 111-114.

Research output: Contribution to journalArticle

Ferko, A, Páral, J, Raupach, J, Chovanec, V, Krajina, A, Měřička, P, Pavcnik, D, Uchida, B, Slížová, D, Krs, O & Nožička, J 2000, 'Autologous vein stent-graft: Feasibility study', Journal of Vascular and Interventional Radiology, vol. 11, no. 1, pp. 111-114.
Ferko A, Páral J, Raupach J, Chovanec V, Krajina A, Měřička P et al. Autologous vein stent-graft: Feasibility study. Journal of Vascular and Interventional Radiology. 2000 Jan;11(1):111-114.
Ferko, Alexander ; Páral, Jiří ; Raupach, Jan ; Chovanec, Vendelin ; Krajina, Antonín ; Měřička, Pavel ; Pavcnik, Dusan ; Uchida, Barry ; Slížová, Dáša ; Krs, Oto ; Nožička, Jan. / Autologous vein stent-graft : Feasibility study. In: Journal of Vascular and Interventional Radiology. 2000 ; Vol. 11, No. 1. pp. 111-114.
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abstract = "PURPOSE: To evaluate expandable stents healed into vein wall as autologous vein stent-grafts for endoluminal grafting. MATERIALS AND METHODS: Balloon expandable stents were placed into external jugular veins of eight dogs. Stent and vein patency was followed by ultrasonography. Five weeks after stent placement, jugular veins with endothelialized stent were harvested? The autologous vein stent-grafts were divided into two groups. In group A, autologous vein stent-grafts (n = 3) were placed immediately into Baker solution for microscopic examination. In group B, autologous vein stent-grafts (n = 3) underwent mechanical manipulation; they were compressed, mounted on angioplasty balloon, pushed through a 9-F sheath and dilated. The autologous vein stent-graft endothelialization and changes after mechanical manipulation were evaluated by light and electron microscopy. RESULTS: Stent placement was successful in seven dogs. One stent migrated into the pulmonary artery. One well placed stent was damaged by compression dressing and thrombosed. At 5 weeks, gross and microscopic examinations revealed the autologous vein stent-grafts were fully covered by a 0.115- ± 0.036-mm thick neointimal layer. Small wall thrombus was observed in one autologous vein stent-graft. Repeated manipulations did not result in any intimal damage or stent loosening in the autologous vein stent-grafts. CONCLUSION: Expandable stents healed into a vein have potential to be used as autologous vein stent- grafts for endoluminal grafting without risk of disruption during percutaneous transcatheter introduction.",
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AU - Páral, Jiří

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AU - Chovanec, Vendelin

AU - Krajina, Antonín

AU - Měřička, Pavel

AU - Pavcnik, Dusan

AU - Uchida, Barry

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N2 - PURPOSE: To evaluate expandable stents healed into vein wall as autologous vein stent-grafts for endoluminal grafting. MATERIALS AND METHODS: Balloon expandable stents were placed into external jugular veins of eight dogs. Stent and vein patency was followed by ultrasonography. Five weeks after stent placement, jugular veins with endothelialized stent were harvested? The autologous vein stent-grafts were divided into two groups. In group A, autologous vein stent-grafts (n = 3) were placed immediately into Baker solution for microscopic examination. In group B, autologous vein stent-grafts (n = 3) underwent mechanical manipulation; they were compressed, mounted on angioplasty balloon, pushed through a 9-F sheath and dilated. The autologous vein stent-graft endothelialization and changes after mechanical manipulation were evaluated by light and electron microscopy. RESULTS: Stent placement was successful in seven dogs. One stent migrated into the pulmonary artery. One well placed stent was damaged by compression dressing and thrombosed. At 5 weeks, gross and microscopic examinations revealed the autologous vein stent-grafts were fully covered by a 0.115- ± 0.036-mm thick neointimal layer. Small wall thrombus was observed in one autologous vein stent-graft. Repeated manipulations did not result in any intimal damage or stent loosening in the autologous vein stent-grafts. CONCLUSION: Expandable stents healed into a vein have potential to be used as autologous vein stent- grafts for endoluminal grafting without risk of disruption during percutaneous transcatheter introduction.

AB - PURPOSE: To evaluate expandable stents healed into vein wall as autologous vein stent-grafts for endoluminal grafting. MATERIALS AND METHODS: Balloon expandable stents were placed into external jugular veins of eight dogs. Stent and vein patency was followed by ultrasonography. Five weeks after stent placement, jugular veins with endothelialized stent were harvested? The autologous vein stent-grafts were divided into two groups. In group A, autologous vein stent-grafts (n = 3) were placed immediately into Baker solution for microscopic examination. In group B, autologous vein stent-grafts (n = 3) underwent mechanical manipulation; they were compressed, mounted on angioplasty balloon, pushed through a 9-F sheath and dilated. The autologous vein stent-graft endothelialization and changes after mechanical manipulation were evaluated by light and electron microscopy. RESULTS: Stent placement was successful in seven dogs. One stent migrated into the pulmonary artery. One well placed stent was damaged by compression dressing and thrombosed. At 5 weeks, gross and microscopic examinations revealed the autologous vein stent-grafts were fully covered by a 0.115- ± 0.036-mm thick neointimal layer. Small wall thrombus was observed in one autologous vein stent-graft. Repeated manipulations did not result in any intimal damage or stent loosening in the autologous vein stent-grafts. CONCLUSION: Expandable stents healed into a vein have potential to be used as autologous vein stent- grafts for endoluminal grafting without risk of disruption during percutaneous transcatheter introduction.

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