Abstract
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.
Original language | English (US) |
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Pages (from-to) | 460-469 |
Number of pages | 10 |
Journal | Ocular Immunology and Inflammation |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - Jul 3 2016 |
Keywords
- Autoinflammation
- HLA-B27
- IL-1
- innate
- spondyloarthritis
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology