Autoinflammation and HLA-B27: Beyond Antigen Presentation

Cailin H. Sibley

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.

Original languageEnglish (US)
Pages (from-to)460-469
Number of pages10
JournalOcular Immunology and Inflammation
Volume24
Issue number4
DOIs
StatePublished - Jul 3 2016

Keywords

  • Autoinflammation
  • HLA-B27
  • IL-1
  • innate
  • spondyloarthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Fingerprint Dive into the research topics of 'Autoinflammation and HLA-B27: Beyond Antigen Presentation'. Together they form a unique fingerprint.

  • Cite this