Autoinflammation and HLA-B27: Beyond Antigen Presentation

Cailin Sibley

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - May 27 2016

Fingerprint

HLA-B27 Antigen
Antigen Presentation
Innate Immunity
Adaptive Immunity
Animal Models

Keywords

  • Autoinflammation
  • HLA-B27
  • IL-1
  • innate
  • spondyloarthritis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

Autoinflammation and HLA-B27 : Beyond Antigen Presentation. / Sibley, Cailin.

In: Ocular Immunology and Inflammation, 27.05.2016, p. 1-10.

Research output: Contribution to journalArticle

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