Autoimmune retinopathy in the absence of cancer

J. B. Mizener, A. E. Kimura, Grazyna Adamus, C. E. Thirkill, J. A. Goeken, R. H. Kardon

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To report the clinical and immunologic features of two patients with progressive retinal degeneration and circulating antiretinal antibodies without systemic malignancy. METHODS: Two patients were followed up for 5 to 7 years. Comprehensive medical and ophthalmic examinations and visual function testing included manual perimetry and standardized electroretinography. Patient sera were tested for antiretinal antibodies by Western blot and immunoperoxidase indirect cytochemistry techniques. RESULTS: Two patients had family history of autoimmune disease. Each had severe monocular visual loss with photopsia, a ring scotoma, and abnormal electroretinogram despite a normal-appearing ocular fundus. One had a flat electroretinogram; the other had inner retina dysfunction, with selective b- wave loss and abnormal oscillatory potentials. Both patients' sera had antiretinal antibodies that specifically labeled the inner plexiform layer of donor retina by indirect immunoperoxidase testing. Neither had any sign of cancer. CONCLUSIONS: In two patients without systemic malignancy, the symptoms, perimetric findings, and normal fundus appearance resembled cancer- associated retinopathy. Electroretinography and antibody findings indicating dysfunction of the inner retina are distinct from those of cancer-associated retinopathy. These two cases raise the possibility of an autoimmune mechanism for retinal degeneration that is not cancer associated. Further study is necessary to determine the role of antiretinal antibodies in these patients.

Original languageEnglish (US)
Pages (from-to)607-618
Number of pages12
JournalAmerican Journal of Ophthalmology
Volume123
Issue number5
StatePublished - 1997
Externally publishedYes

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Ocular Paraneoplastic Syndromes
Neoplasms
Antibodies
Electroretinography
Retina
Retinal Degeneration
Scotoma
Histocytochemistry
Visual Field Tests
Serum
Autoimmune Diseases
Western Blotting
Tissue Donors

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mizener, J. B., Kimura, A. E., Adamus, G., Thirkill, C. E., Goeken, J. A., & Kardon, R. H. (1997). Autoimmune retinopathy in the absence of cancer. American Journal of Ophthalmology, 123(5), 607-618.

Autoimmune retinopathy in the absence of cancer. / Mizener, J. B.; Kimura, A. E.; Adamus, Grazyna; Thirkill, C. E.; Goeken, J. A.; Kardon, R. H.

In: American Journal of Ophthalmology, Vol. 123, No. 5, 1997, p. 607-618.

Research output: Contribution to journalArticle

Mizener, JB, Kimura, AE, Adamus, G, Thirkill, CE, Goeken, JA & Kardon, RH 1997, 'Autoimmune retinopathy in the absence of cancer', American Journal of Ophthalmology, vol. 123, no. 5, pp. 607-618.
Mizener JB, Kimura AE, Adamus G, Thirkill CE, Goeken JA, Kardon RH. Autoimmune retinopathy in the absence of cancer. American Journal of Ophthalmology. 1997;123(5):607-618.
Mizener, J. B. ; Kimura, A. E. ; Adamus, Grazyna ; Thirkill, C. E. ; Goeken, J. A. ; Kardon, R. H. / Autoimmune retinopathy in the absence of cancer. In: American Journal of Ophthalmology. 1997 ; Vol. 123, No. 5. pp. 607-618.
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