Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats

Madison Kyger; Aneta Worley; Grazyna Adamus

doi:10.1016/j.jneuroim.2012.10.007

Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats

Madison Kyger, Aneta Worley, Grazyna Adamus

Ophthalmology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Autoimmunity may contribute to retinal degeneration. The studies examined the evolution of autoimmune responses against retina in naïve dystrophic RCS rats over the course of retinal degeneration. We showed that anti-retinal autoantibodies and T cells are generated in response to the availability of antigenic material released from dying photoreceptor cells during retinal degeneration but with distinctive activation trends. Passive transfer of anti-retinal antibodies enhanced disease progression by disrupting the BRB, upregulating MCP-1, attracting blood macrophages into retina, and augmenting apoptotic photoreceptor cell death. Our findings directly link anti-retinal autoantibodies to activated macrophage entry and their possible role in neurodegeneration.

Original language	English (US)
Pages (from-to)	91-100
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	254
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.10.007
State	Published - Jan 15 2013

Keywords

Autoantibody
Autoimmunity
Macrophages
Passive transfer
RCS rat
Retinal degeneration

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2012.10.007

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title = "Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats",

abstract = "Autoimmunity may contribute to retinal degeneration. The studies examined the evolution of autoimmune responses against retina in na{\"i}ve dystrophic RCS rats over the course of retinal degeneration. We showed that anti-retinal autoantibodies and T cells are generated in response to the availability of antigenic material released from dying photoreceptor cells during retinal degeneration but with distinctive activation trends. Passive transfer of anti-retinal antibodies enhanced disease progression by disrupting the BRB, upregulating MCP-1, attracting blood macrophages into retina, and augmenting apoptotic photoreceptor cell death. Our findings directly link anti-retinal autoantibodies to activated macrophage entry and their possible role in neurodegeneration.",

keywords = "Autoantibody, Autoimmunity, Macrophages, Passive transfer, RCS rat, Retinal degeneration",

author = "Madison Kyger and Aneta Worley and Grazyna Adamus",

note = "Funding Information: The authors thank Dr. Hugh McDowell and W. Clay Smith for purified arrestin sample for the studies. This research has been supported in part by the OCTRI 5 UL1 RR 024140 and unrestricted grant from the RPB to Casey Eye Institute.",

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AU - Worley, Aneta

AU - Adamus, Grazyna

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PY - 2013/1/15

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AB - Autoimmunity may contribute to retinal degeneration. The studies examined the evolution of autoimmune responses against retina in naïve dystrophic RCS rats over the course of retinal degeneration. We showed that anti-retinal autoantibodies and T cells are generated in response to the availability of antigenic material released from dying photoreceptor cells during retinal degeneration but with distinctive activation trends. Passive transfer of anti-retinal antibodies enhanced disease progression by disrupting the BRB, upregulating MCP-1, attracting blood macrophages into retina, and augmenting apoptotic photoreceptor cell death. Our findings directly link anti-retinal autoantibodies to activated macrophage entry and their possible role in neurodegeneration.

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KW - Macrophages

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Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats

Abstract

Keywords

ASJC Scopus subject areas

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