Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats

Madison Kyger, Aneta Worley, Grazyna Adamus

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Autoimmunity may contribute to retinal degeneration. The studies examined the evolution of autoimmune responses against retina in naïve dystrophic RCS rats over the course of retinal degeneration. We showed that anti-retinal autoantibodies and T cells are generated in response to the availability of antigenic material released from dying photoreceptor cells during retinal degeneration but with distinctive activation trends. Passive transfer of anti-retinal antibodies enhanced disease progression by disrupting the BRB, upregulating MCP-1, attracting blood macrophages into retina, and augmenting apoptotic photoreceptor cell death. Our findings directly link anti-retinal autoantibodies to activated macrophage entry and their possible role in neurodegeneration.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalJournal of Neuroimmunology
Volume254
Issue number1-2
DOIs
StatePublished - Jan 15 2013

Keywords

  • Autoantibody
  • Autoimmunity
  • Macrophages
  • Passive transfer
  • RCS rat
  • Retinal degeneration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats'. Together they form a unique fingerprint.

  • Cite this