TY - JOUR
T1 - Autocrine regulation of neural chest cell development by steel factor
AU - Guo, Chang Sheng
AU - Wehrle-Haller, Bernhard
AU - Rossi, John
AU - Ciment, Gary
N1 - Funding Information:
We thank Dr. A. Johnson (Rutger's University, New Brunswick, NJ), Dr. J. Carnahan (Amgen, Inc., Thousand Oaks, CA), and Dr. M. Sakurai (National Institute of Animal Health, Japan) for their generous gifts of chicken SLF cDNA, recombinant chicken SLF protein, and chicken c-kit cDNA, respectively. We also thank Drs. Gabrielle Leblanc and Steven Matsumoto for their helpful comments on the manuscript. This work was supported by a grant from the NIH to G.C.
PY - 1997/4/1
Y1 - 1997/4/1
N2 - Steel factor (SLF) and its cognate receptor, c-kit, have been implicated in the generation of melanocytes from migrating neural crest (NC) cells during early vertebrate embryogenesis. However, the source of SLF in the early avian embryo and its precise role in melanogenesis are unclear. We report here that NC cells themselves express and release SLF protein, which in turn acts as an autocrine factor to induce melanogenesis in nearly NC cells. These results indicate that NC cell subpopulations play an active role in the determination of their cell fate and suggest a different developmental role for the embryonic microenvironment than what has been previously proposed.
AB - Steel factor (SLF) and its cognate receptor, c-kit, have been implicated in the generation of melanocytes from migrating neural crest (NC) cells during early vertebrate embryogenesis. However, the source of SLF in the early avian embryo and its precise role in melanogenesis are unclear. We report here that NC cells themselves express and release SLF protein, which in turn acts as an autocrine factor to induce melanogenesis in nearly NC cells. These results indicate that NC cell subpopulations play an active role in the determination of their cell fate and suggest a different developmental role for the embryonic microenvironment than what has been previously proposed.
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U2 - 10.1006/dbio.1997.8520
DO - 10.1006/dbio.1997.8520
M3 - Article
C2 - 9142984
AN - SCOPUS:0031127424
SN - 0012-1606
VL - 184
SP - 61
EP - 69
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -