Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts

J. S. Norris; L. E. Cornett; J. W. Hardin; P. O. Kohler; S. L. MacLeod; A. Srivastava; A. J. Syms; R. G. Smith

doi:10.1016/0006-291X(84)90448-0

Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts

J. S. Norris, L. E. Cornett, J. W. Hardin, P. O. Kohler, S. L. MacLeod, A. Srivastava, A. J. Syms, R. G. Smith

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19 Scopus citations

Abstract

The ductus deferens smooth muscle tumor cell line (DDT₁MF-2) expresses c-sis protooncogene poly A⁺ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT₁MF-2 cells in G₀ G₁ stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A⁺ transcripts, which we suggest are encoding a PDGF-like molecule for DDT₁MF-2 cells.

Original language	English (US)
Pages (from-to)	124-128
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(84)90448-0
State	Published - Jul 18 1984
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts",

abstract = "The ductus deferens smooth muscle tumor cell line (DDT1MF-2) expresses c-sis protooncogene poly A+ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT1MF-2 cells in G0 G1 stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A+ transcripts, which we suggest are encoding a PDGF-like molecule for DDT1MF-2 cells.",

author = "Norris, {J. S.} and Cornett, {L. E.} and Hardin, {J. W.} and Kohler, {P. O.} and MacLeod, {S. L.} and A. Srivastava and Syms, {A. J.} and Smith, {R. G.}",

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AU - Norris, J. S.

AU - Cornett, L. E.

AU - Hardin, J. W.

AU - Kohler, P. O.

AU - MacLeod, S. L.

AU - Srivastava, A.

AU - Syms, A. J.

AU - Smith, R. G.

PY - 1984/7/18

Y1 - 1984/7/18

N2 - The ductus deferens smooth muscle tumor cell line (DDT1MF-2) expresses c-sis protooncogene poly A+ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT1MF-2 cells in G0 G1 stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A+ transcripts, which we suggest are encoding a PDGF-like molecule for DDT1MF-2 cells.

AB - The ductus deferens smooth muscle tumor cell line (DDT1MF-2) expresses c-sis protooncogene poly A+ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT1MF-2 cells in G0 G1 stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A+ transcripts, which we suggest are encoding a PDGF-like molecule for DDT1MF-2 cells.

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Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts

Abstract

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