Autocrine regulation of growth: II. Glucocorticoids inhibit transcription of c-sis oncogene-specific RNA transcripts

J. S. Norris, L. E. Cornett, J. W. Hardin, Peter Kohler, S. L. MacLeod, A. Srivastava, A. J. Syms, R. G. Smith

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The ductus deferens smooth muscle tumor cell line (DDT1MF-2) expresses c-sis protooncogene poly A+ RNA transcripts which are thought to encode at least one subunit of the potent mitogen platelet derived growth factor (PDGF). We have previously demonstrated that glucocorticoids block DDT1MF-2 cells in G0 G1 stage of the cell cycle, and that exogenously applied PDGF reinitiates cell cycle progression. In this paper we document that glucocorticoids act to inhibit cell cycle progression by inhibiting the expression of c-sis poly A+ transcripts, which we suggest are encoding a PDGF-like molecule for DDT1MF-2 cells.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume122
Issue number1
DOIs
Publication statusPublished - Jul 18 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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