Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction

H. A. Ingraham, Y. Hirokawa, L. M. Roberts, S. H. Mellon, E. McGee, M. W. Nachtigal, J. A. Visser, W. Schrader, J. Cidlowski, Sergio Ojeda, G. Cutler, S. Kawashima

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Members of the transforming growth factor beta (TGFβ) superfamily are polypeptide growth factors that exhibit diverse effects on normal cell growth, adhesion, mesenchymal-epithelial interactions, cell differentiation, and programmed cell death. This chapter will discuss the work of ourselves and others on one member of this large superfamily, Müllerian inhibiting substance (MIS, or anti-Müllerian hormone, AMH) and its role in reproductive tract development and the adult gonad. Using recombinant MIS protein, it is possible to begin unraveling the molecular mechanism of duct involution in the embryo. Our recent results suggest that MIS triggers cell death by altering mesenchymal-epithelial interactions. In addition to the developmental effects of MIS in secondary sexual differentiation, expression studies of the MIS ligand and the MIS type II receptor (MISIIR) suggest a potential regulatory role for MIS in adult germ cell maturation and gonadal function. Recent data from others suggest that MIS may act in a paracrine manner to block differentiation of interstitial cells of the adult gonad by repressing all or some steps of steroidogenesis. Our studies are highly suggestive of direct repression of steroidogenic enzyme gene expression by activation of the MIS signaling pathway. Thus, for the first time, an opportunity to define fully target genes and components of the MIS signaling pathway may be possible.

Original languageEnglish (US)
Pages (from-to)53-68
Number of pages16
JournalRecent Progress in Hormone Research
Volume55
StatePublished - 2000
Externally publishedYes

Fingerprint

Gonads
Reproduction
Cell Differentiation
Enzyme Repression
Cell Death
Hormones
Gene Components
Sex Differentiation
Recombinant Proteins
Cell Adhesion
Germ Cells
Transforming Growth Factor beta
Transcriptional Activation
Intercellular Signaling Peptides and Proteins
Embryonic Structures
Epithelial Cells
Ligands
Gene Expression
Peptides
Growth

ASJC Scopus subject areas

  • Endocrinology

Cite this

Ingraham, H. A., Hirokawa, Y., Roberts, L. M., Mellon, S. H., McGee, E., Nachtigal, M. W., ... Kawashima, S. (2000). Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction. Recent Progress in Hormone Research, 55, 53-68.

Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction. / Ingraham, H. A.; Hirokawa, Y.; Roberts, L. M.; Mellon, S. H.; McGee, E.; Nachtigal, M. W.; Visser, J. A.; Schrader, W.; Cidlowski, J.; Ojeda, Sergio; Cutler, G.; Kawashima, S.

In: Recent Progress in Hormone Research, Vol. 55, 2000, p. 53-68.

Research output: Contribution to journalArticle

Ingraham, HA, Hirokawa, Y, Roberts, LM, Mellon, SH, McGee, E, Nachtigal, MW, Visser, JA, Schrader, W, Cidlowski, J, Ojeda, S, Cutler, G & Kawashima, S 2000, 'Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction', Recent Progress in Hormone Research, vol. 55, pp. 53-68.
Ingraham HA, Hirokawa Y, Roberts LM, Mellon SH, McGee E, Nachtigal MW et al. Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction. Recent Progress in Hormone Research. 2000;55:53-68.
Ingraham, H. A. ; Hirokawa, Y. ; Roberts, L. M. ; Mellon, S. H. ; McGee, E. ; Nachtigal, M. W. ; Visser, J. A. ; Schrader, W. ; Cidlowski, J. ; Ojeda, Sergio ; Cutler, G. ; Kawashima, S. / Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction. In: Recent Progress in Hormone Research. 2000 ; Vol. 55. pp. 53-68.
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