Autoantibodies to transducin in a patient with melanoma-associated retinopathy

Michael J. Potter, Grazyna Adamus, Shelagh M. Szabo, Rehwa Lee, Kam Mohaseb, Darren Behn

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

PURPOSE: To report novel immunoreactivity in a patient with melanoma-associated retinopathy. DESIGN: Retrospective case report and experimental study. METHODS: A 32-year-old woman with a history of metastatic melanoma presented with bilateral decreased visual acuity. Electroretinography, Goldmann perimetry, immunohistochemistry, and Western blotting of her serum were performed. RESULTS: Electroretinography showed a "negative" B-wave. Paracentral and central scotomas were observed on Goldmann perimetry. Antibodies to a retinal transducin were demonstrated by Western blotting. No immunoreactivity to retinal bipolar cells was detected by immunohistochemistry. CONCLUSION: Melanoma-associated retinopathy can be related to a variety of antiretinal antibodies. Recognition of transducin, a novel melanoma-associated retinopathy antigen, may be important for identifying and treating patients with night blindness and melanoma.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume134
Issue number1
DOIs
StatePublished - 2002

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Ocular Paraneoplastic Syndromes
Transducin
Autoantibodies
Electroretinography
Scotoma
Visual Field Tests
Melanoma
Retinal Bipolar Cells
Western Blotting
Immunohistochemistry
Night Blindness
Antibodies
Visual Acuity
Antigens
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Autoantibodies to transducin in a patient with melanoma-associated retinopathy. / Potter, Michael J.; Adamus, Grazyna; Szabo, Shelagh M.; Lee, Rehwa; Mohaseb, Kam; Behn, Darren.

In: American Journal of Ophthalmology, Vol. 134, No. 1, 2002, p. 128-130.

Research output: Contribution to journalArticle

Potter, Michael J. ; Adamus, Grazyna ; Szabo, Shelagh M. ; Lee, Rehwa ; Mohaseb, Kam ; Behn, Darren. / Autoantibodies to transducin in a patient with melanoma-associated retinopathy. In: American Journal of Ophthalmology. 2002 ; Vol. 134, No. 1. pp. 128-130.
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