Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity

Oleg Sokolov, Natalya Kost, Olga Andreeva, Ekaterina Korneeva, Viktor Meshavkin, Yulia Tarakanova, Aleksander Dadayan, Yurii Zolotarev, Sergei Grachev, Inna Mikheeva, Oleg Varlamov, Andrey Zozulya

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Elevated concentrations of circulating casomorphins (CM), the exogenous opioid peptides from milk casein, may contribute to the pathogenesis of autism in children. Because several mass spectrometry studies failed to detect casomorphins in autistic children, it was questioned whether these peptides can be detected in body fluids by mass spec. Here we demonstrated, using a novel high sensitivity ELISA method, that autistic children have significantly higher levels of urine CM-7 than control children. The severity of autistic symptoms correlated with concentrations of CM-7 in the urine. Because CMs interact with opioid and serotonin receptors, the known modulators of synaptogenesis, we suggest that chronic exposure to elevated levels of bovine CMs may impair early child development, setting the stage for autistic disorders.

    Original languageEnglish (US)
    Pages (from-to)68-71
    Number of pages4
    JournalPeptides
    Volume56
    DOIs
    StatePublished - 2014

    Fingerprint

    Opioid Peptides
    Serotonin Receptors
    Body fluids
    Opioid Receptors
    Caseins
    Modulators
    Mass spectrometry
    Urine
    Peptides
    Autistic Disorder
    Body Fluids
    Child Development
    Mass Spectrometry
    Milk
    Enzyme-Linked Immunosorbent Assay

    Keywords

    • Autism
    • Bovine casomorphin
    • Opioid peptides
    • Urine

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Physiology
    • Cellular and Molecular Neuroscience
    • Medicine(all)

    Cite this

    Sokolov, O., Kost, N., Andreeva, O., Korneeva, E., Meshavkin, V., Tarakanova, Y., ... Zozulya, A. (2014). Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity. Peptides, 56, 68-71. https://doi.org/10.1016/j.peptides.2014.03.007

    Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity. / Sokolov, Oleg; Kost, Natalya; Andreeva, Olga; Korneeva, Ekaterina; Meshavkin, Viktor; Tarakanova, Yulia; Dadayan, Aleksander; Zolotarev, Yurii; Grachev, Sergei; Mikheeva, Inna; Varlamov, Oleg; Zozulya, Andrey.

    In: Peptides, Vol. 56, 2014, p. 68-71.

    Research output: Contribution to journalArticle

    Sokolov, O, Kost, N, Andreeva, O, Korneeva, E, Meshavkin, V, Tarakanova, Y, Dadayan, A, Zolotarev, Y, Grachev, S, Mikheeva, I, Varlamov, O & Zozulya, A 2014, 'Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity', Peptides, vol. 56, pp. 68-71. https://doi.org/10.1016/j.peptides.2014.03.007
    Sokolov O, Kost N, Andreeva O, Korneeva E, Meshavkin V, Tarakanova Y et al. Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity. Peptides. 2014;56:68-71. https://doi.org/10.1016/j.peptides.2014.03.007
    Sokolov, Oleg ; Kost, Natalya ; Andreeva, Olga ; Korneeva, Ekaterina ; Meshavkin, Viktor ; Tarakanova, Yulia ; Dadayan, Aleksander ; Zolotarev, Yurii ; Grachev, Sergei ; Mikheeva, Inna ; Varlamov, Oleg ; Zozulya, Andrey. / Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity. In: Peptides. 2014 ; Vol. 56. pp. 68-71.
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    abstract = "Elevated concentrations of circulating casomorphins (CM), the exogenous opioid peptides from milk casein, may contribute to the pathogenesis of autism in children. Because several mass spectrometry studies failed to detect casomorphins in autistic children, it was questioned whether these peptides can be detected in body fluids by mass spec. Here we demonstrated, using a novel high sensitivity ELISA method, that autistic children have significantly higher levels of urine CM-7 than control children. The severity of autistic symptoms correlated with concentrations of CM-7 in the urine. Because CMs interact with opioid and serotonin receptors, the known modulators of synaptogenesis, we suggest that chronic exposure to elevated levels of bovine CMs may impair early child development, setting the stage for autistic disorders.",
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