Autism spectrum disorders associated with X chromosome markers in French-Canadian males

J. Gauthier, R. Joober, M. P. Dubé, J. St-Onge, A. Bonnel, D. Gariépy, S. Laurent, R. Najafee, H. Lacasse, L. St-Charles, É Fombonne, L. Mottron, G. A. Rouleau

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P = 0.026) and DXS8043 (P = 0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value = 0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.

Original languageEnglish (US)
Pages (from-to)206-213
Number of pages8
JournalMolecular Psychiatry
Volume11
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Association study
  • Autism spectrum disorders
  • French-Canadian
  • Haplotype analysis
  • X chromosome

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Gauthier, J., Joober, R., Dubé, M. P., St-Onge, J., Bonnel, A., Gariépy, D., Laurent, S., Najafee, R., Lacasse, H., St-Charles, L., Fombonne, É., Mottron, L., & Rouleau, G. A. (2006). Autism spectrum disorders associated with X chromosome markers in French-Canadian males. Molecular Psychiatry, 11(2), 206-213. https://doi.org/10.1038/sj.mp.4001756