Abstract
It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P = 0.026) and DXS8043 (P = 0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value = 0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.
Original language | English (US) |
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Pages (from-to) | 206-213 |
Number of pages | 8 |
Journal | Molecular Psychiatry |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2006 |
Externally published | Yes |
Keywords
- Association study
- Autism spectrum disorders
- French-Canadian
- Haplotype analysis
- X chromosome
ASJC Scopus subject areas
- Molecular Biology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience