Aureomycin in experimental acute pancreatitis of dogs

Lester Persky, Fritz B. Schweinburg, Stanley Jacob, Jacob Fine

Research output: Research - peer-reviewArticle

  • 12 Citations

Abstract

1. 1. A lethal acute hemorrhagic pancreatitis was produced regularly in dogs by an injection of 10 c.c. of bile into the pancreatic duct. 2. 2. Aureomycin given orally for several days before or after injection of the bile resulted in 100 per cent survival. 3. 3. Intravenous aureomycin or parenteral penicillin therapy resulted in survival in only 40 per cent. 4. 4. Bacteriologic studies confirm conclusions from earlier work that the normal liver and pancreas of dogs frequently harbor microorganisms, predominantly Clostridia. 5. 5. In dogs dying of hemorrhagic pancreatitis there is a marked increase in bacteria, particularly Clostridia, in liver and pancreas as well as a high incidence of Clostridia in peritoneal fluid and in portal vein blood. 6. 6. Since the survival rate by the prophylactic use of polyvalent gas gangrene antitoxin was 60 per cent, it is apparent that the Clostridia are a dominating influence in the lethal outcome of the untreated disease. 7. 7. The much greater effectiveness of the oral as compared to the parenteral route of administration of the antibiotic indicates that the organisms which invade the tissues from the intestine following the onset of pancreatitis are the major source of the pathogenic organisms involved in the lethal outcome of this disease in dogs.

LanguageEnglish (US)
Pages652-656
Number of pages5
JournalSurgery
Volume30
Issue number4
StatePublished - Oct 1951
Externally publishedYes

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Chlortetracycline
Clostridium
Pancreatitis
Dogs
Bile
Pancreas
Injections
Liver
Gas Gangrene
Dog Diseases
Antitoxins
Pancreatic Ducts
Ascitic Fluid
Portal Vein
Penicillins
Intestines
Anti-Bacterial Agents
Bacteria
Incidence
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Persky, L., Schweinburg, F. B., Jacob, S., & Fine, J. (1951). Aureomycin in experimental acute pancreatitis of dogs. Surgery, 30(4), 652-656.

Aureomycin in experimental acute pancreatitis of dogs. / Persky, Lester; Schweinburg, Fritz B.; Jacob, Stanley; Fine, Jacob.

In: Surgery, Vol. 30, No. 4, 10.1951, p. 652-656.

Research output: Research - peer-reviewArticle

Persky, L, Schweinburg, FB, Jacob, S & Fine, J 1951, 'Aureomycin in experimental acute pancreatitis of dogs' Surgery, vol 30, no. 4, pp. 652-656.
Persky L, Schweinburg FB, Jacob S, Fine J. Aureomycin in experimental acute pancreatitis of dogs. Surgery. 1951 Oct;30(4):652-656.
Persky, Lester ; Schweinburg, Fritz B. ; Jacob, Stanley ; Fine, Jacob. / Aureomycin in experimental acute pancreatitis of dogs. In: Surgery. 1951 ; Vol. 30, No. 4. pp. 652-656
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AB - 1. 1. A lethal acute hemorrhagic pancreatitis was produced regularly in dogs by an injection of 10 c.c. of bile into the pancreatic duct. 2. 2. Aureomycin given orally for several days before or after injection of the bile resulted in 100 per cent survival. 3. 3. Intravenous aureomycin or parenteral penicillin therapy resulted in survival in only 40 per cent. 4. 4. Bacteriologic studies confirm conclusions from earlier work that the normal liver and pancreas of dogs frequently harbor microorganisms, predominantly Clostridia. 5. 5. In dogs dying of hemorrhagic pancreatitis there is a marked increase in bacteria, particularly Clostridia, in liver and pancreas as well as a high incidence of Clostridia in peritoneal fluid and in portal vein blood. 6. 6. Since the survival rate by the prophylactic use of polyvalent gas gangrene antitoxin was 60 per cent, it is apparent that the Clostridia are a dominating influence in the lethal outcome of the untreated disease. 7. 7. The much greater effectiveness of the oral as compared to the parenteral route of administration of the antibiotic indicates that the organisms which invade the tissues from the intestine following the onset of pancreatitis are the major source of the pathogenic organisms involved in the lethal outcome of this disease in dogs.

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