Auranofin: 1 mg or 9 mg? The search for the appropriate dose

A. Calin, D. Saunders, Robert (Rob) Bennett

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Auranofin (AF) was given to 2 groups of patients, one receiving 1 mg daily (56 patients), the other 9 mg (60 patients) in a double-blind manner. Significantly fewer patients on 1 mg (7%) reduced dosage or dropped out because of side effects than did those on high dose (27%; p <0.05). Dropouts related to skin rash while dose reduction was necessitated by self-limiting diarrhea. Significantly more patients on low dose dropped out because of lack of efficacy than did those on high dose.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalJournal of Rheumatology
Volume9
Issue numberSuppl. 8
Publication statusPublished - 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Rheumatology
  • Medicine(all)

Cite this

Calin, A., Saunders, D., & Bennett, R. R. (1982). Auranofin: 1 mg or 9 mg? The search for the appropriate dose. Journal of Rheumatology, 9(Suppl. 8), 146-148.