Augmentation of Rabbit Posterolateral Spondylodesis Using a Novel Demineralized Bone Matrix-Hyaluronan Putty

Albert Juang Ming Yee, Hyun W. Bae, Darin Friess, Mark Robbin, Brian Johnstone, Jung U. Yoo

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Study Design. Posterolateral spinal fusion with allogeneic demineralized bone graft-hyaluronan putty in addition to autogenous iliac crest bone graft in a rabbit model. Objectives. To determine the potential efficacy of demineralized bone graft-hyaluronan putty as a bone graft enhancer. Summary of Background Data. Autograft bone is the material of choice for posterolateral lumbar intertransverse process fusion. Bone graft alternatives such as demineralized bone matrices that can be used as graft extenders, enhancers, or substitutes continue to be developed. Methods. One hundred New Zealand white rabbits underwent bilateral posterolateral spinal fusion with autogenous iliac crest bone graft or bone graft with allogeneic rabbit demineralized bone graft-hypluronan putty. The rabbits were killed 9 weeks later, and the lumbar spines were removed. Manual manipulation and fine detail radiography were used to assess spinal fusion, and computed tomographic images were used to quantify the volume of the fusion mass. Results. In comparison with autograft bone alone, the fusion rates were greater when demineralized bone graft-hyaluronan putty was used as an adjunct to autogenous bone. Furthermore, the radiographic fusion rate was greater when demineralized bone graft-hyaluronan putty was used in a 2:1 ratio to autograft bone in comparison with a 1:1 ratio (P = 0.001). The addition of demineralized bone graft-hyaluronan putty to autograft bone was found to increase mineralized bone volume in a ratio-dependent manner (P < 0.05). Conclusions. Allogeneic demineralized bone matrix-hyaluronan putty enhances rabbit posterolateral spin fusion when used as an adjunct to autogenous bone graft. This new formulation of demineralized bone matrix may facilitate greater bone formation and successful fusion.

Original languageEnglish (US)
Pages (from-to)2435-2440
Number of pages6
JournalSpine
Volume28
Issue number21
DOIs
StatePublished - Nov 1 2003

Keywords

  • Bone graft
  • Demineralized bone matrix
  • Hyaluronan
  • Spine fusion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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