Augmentation of acth-releasing activity op synthetic corticotropin releasing factor (crf) by vasopressin in women

J. H. Liu; K. Muse; P. Contreras; D. Gibbs; W. Vale; J. Rivier; S. S.C. Yen

doi:10.1210/jcem-57-5-1087

Augmentation of acth-releasing activity op synthetic corticotropin releasing factor (crf) by vasopressin in women

J. H. Liu, K. Muse, P. Contreras, D. Gibbs, W. Vale, J. Rivier, S. S.C. Yen

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

In order to study the interaction between vasopressin (VP) and hypothalamic corticotropin releasing factor (CRF) on the release of ACTH, VP and CRF were administered separately and in combination to normal cycling women. The combined hormones raised plasma ACTH levels higher than the sum of the separate responses and 5 times more than CRF alone. This study reveals for the first time synergism between VP and CRF in their ACTH releasing effects in humans.

Original language	English (US)
Pages (from-to)	1087-1089
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	57
Issue number	5
DOIs	https://doi.org/10.1210/jcem-57-5-1087
State	Published - Nov 1983
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-57-5-1087

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AU - Muse, K.

AU - Contreras, P.

AU - Gibbs, D.

AU - Vale, W.

AU - Rivier, J.

AU - Yen, S. S.C.

PY - 1983/11

Y1 - 1983/11

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Augmentation of acth-releasing activity op synthetic corticotropin releasing factor (crf) by vasopressin in women

Abstract

ASJC Scopus subject areas

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