Augmentation of acth-releasing activity op synthetic corticotropin releasing factor (crf) by vasopressin in women

J. H. Liu, K. Muse, P. Contreras, D. Gibbs, W. Vale, J. Rivier, S. S.C. Yen

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

In order to study the interaction between vasopressin (VP) and hypothalamic corticotropin releasing factor (CRF) on the release of ACTH, VP and CRF were administered separately and in combination to normal cycling women. The combined hormones raised plasma ACTH levels higher than the sum of the separate responses and 5 times more than CRF alone. This study reveals for the first time synergism between VP and CRF in their ACTH releasing effects in humans.

Original languageEnglish (US)
Pages (from-to)1087-1089
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume57
Issue number5
DOIs
StatePublished - Nov 1983

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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