Auditory function in the C3H/HeJ and C3H/HeSnJ mouse strains

Dennis R. Trune; J. Beth Kempton; Curtin Mitchell

doi:10.1016/0378-5955(96)00017-2

Auditory function in the C3H/HeJ and C3H/HeSnJ mouse strains

Dennis R. Trune, J. Beth Kempton, Curtin Mitchell

Otolaryngology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The C3H inbred mouse strain arose in 1920 and includes several substrains, such as the C3H/HeJ and C3H/HeSnJ variants. However, use of these C3H mice in hearing research has been limited because their auditory function has not been described. Therefore, the purpose of this study was to characterize auditory function in two C3H representative substrains, C3H/HeJ and C3H/HeSnJ mice were obtained from Jackson Laboratories for auditory brainstem response (ABR) testing at ages from 2 to 30 months. Animals were tested with tone bursts at frequencies of 4, 8, 16, 24, and 32 kHz. These early responses were evaluated for age-related threshold shifts as an index of peripheral auditory function. Both strains show normal sensitivity up to 14 months of age. Thresholds for both strains were slightly elevated at most frequencies at 18 months. C3H/HeSnJ mice tested at 30 months demonstrated little hearing function due to extensive sensorineural degeneration. Thus, these C3H strains maintain excellent cochlear function past 1 year of age.

Original language	English (US)
Pages (from-to)	41-45
Number of pages	5
Journal	Hearing Research
Volume	96
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5955(96)00017-2
State	Published - Jul 1996

Keywords

Auditory brainstem response
C3H/HeJ substrain
C3H/HeSnJ substrain
Inner ear
Mouse

ASJC Scopus subject areas

Sensory Systems

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title = "Auditory function in the C3H/HeJ and C3H/HeSnJ mouse strains",

abstract = "The C3H inbred mouse strain arose in 1920 and includes several substrains, such as the C3H/HeJ and C3H/HeSnJ variants. However, use of these C3H mice in hearing research has been limited because their auditory function has not been described. Therefore, the purpose of this study was to characterize auditory function in two C3H representative substrains, C3H/HeJ and C3H/HeSnJ mice were obtained from Jackson Laboratories for auditory brainstem response (ABR) testing at ages from 2 to 30 months. Animals were tested with tone bursts at frequencies of 4, 8, 16, 24, and 32 kHz. These early responses were evaluated for age-related threshold shifts as an index of peripheral auditory function. Both strains show normal sensitivity up to 14 months of age. Thresholds for both strains were slightly elevated at most frequencies at 18 months. C3H/HeSnJ mice tested at 30 months demonstrated little hearing function due to extensive sensorineural degeneration. Thus, these C3H strains maintain excellent cochlear function past 1 year of age.",

keywords = "Auditory brainstem response, C3H/HeJ substrain, C3H/HeSnJ substrain, Inner ear, Mouse",

author = "Trune, {Dennis R.} and Kempton, {J. Beth} and Curtin Mitchell",

note = "Funding Information: Special thanks are due Jackie DeGagne and Barbara Larrain for histological and digital photographic assistance. This research was supported in part by research Grant 5 R01 DC 01052-03 from the National Institute on Deafness and Other Communication Disorders, National Institutes of Health, and Grant H235 K30001 from the Department of Education.",

year = "1996",

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doi = "10.1016/0378-5955(96)00017-2",

language = "English (US)",

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AU - Mitchell, Curtin

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PY - 1996/7

Y1 - 1996/7

N2 - The C3H inbred mouse strain arose in 1920 and includes several substrains, such as the C3H/HeJ and C3H/HeSnJ variants. However, use of these C3H mice in hearing research has been limited because their auditory function has not been described. Therefore, the purpose of this study was to characterize auditory function in two C3H representative substrains, C3H/HeJ and C3H/HeSnJ mice were obtained from Jackson Laboratories for auditory brainstem response (ABR) testing at ages from 2 to 30 months. Animals were tested with tone bursts at frequencies of 4, 8, 16, 24, and 32 kHz. These early responses were evaluated for age-related threshold shifts as an index of peripheral auditory function. Both strains show normal sensitivity up to 14 months of age. Thresholds for both strains were slightly elevated at most frequencies at 18 months. C3H/HeSnJ mice tested at 30 months demonstrated little hearing function due to extensive sensorineural degeneration. Thus, these C3H strains maintain excellent cochlear function past 1 year of age.

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Auditory function in the C3H/HeJ and C3H/HeSnJ mouse strains

Abstract

Keywords

ASJC Scopus subject areas

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