Auditory conditional discrimination deficits without delays in rats with lesions of either frontal cortex or medial thalamus

Alexander Stevens, Robert G. Mair

Research output: Contribution to journalArticle

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Abstract

An auditory match-to-position (AMTP) task was developed to compare the effects of medial thalamic (L-IML) and prefrontal cortical (MW) lesions on the ability of rats to perform conditional discriminations with and without memory delays. Both lesions affected AMTP when there was no delay, and these impairments were not exacerbated when memory delays were imposed. The MW group performed normally, whereas the L-IML group was impaired in learning a go/no-go discrimination based on the same auditory stimuli as those used for AMTP. These findings are consistent with other evidence that the medial prefrontal cortex is critical for conditional associative learning when the same response alternatives are presented repeatedly across trials. The impairments observed for AMTP when there was no memory delay suggest that the effects of these lesions on the rate of forgetting may have been masked by the effects of these lesions on nonmnemonic aspects of the AMTP task.

Original languageEnglish (US)
Pages (from-to)205-215
Number of pages11
JournalPsychobiology
Volume26
Issue number3
Publication statusPublished - 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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