Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism

Jennifer Peraza, Anita Cservenka, Megan M. Herting, Bonnie Nagel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Adults with alcohol use disorders (AUDs) show different behavioral and neurological functioning during emotional processing tasks from healthy controls. Adults with a family history (FHP) of AUD also show different activation in limbic brain areas, such as the amygdala. However, it is unclear if this pattern exists during adolescence before any episodes of heavy alcohol use. Objectives: We hypothesized that the amygdalar response to subliminally-presented fearful faces would be reduced in FHP adolescents compared to peers who were family history negative (FHN) for AUD. Method: An adapted Masked Faces paradigm was used to examine blood oxygen level-dependent response to subliminal fearful vs. neutral faces in 14 FHP (6 females, 8 males) and 15 FHN (6 females, 9 males) youth, ages 11-15 years. Both FHP and FHN youth had no history of heavy alcohol consumption. Results: A significant difference was seen between groups in the left superior parietal lobule FHN youth showed deactivation to fearful and neutral masked faces compared to baseline, whereas FHP youth showed deactivation only to fearful masked faces. No significant differences in amygdalar activation were seen between groups. Conclusion: The left superior parietal lobule is part of the fronto-parietal network, which has been implicated in attentional control. Lack of reduced neural activity to neutral faces among FHP youth may represent differences in suppressing attention networks to less salient emotional stimuli, or perhaps, a higher threshold of saliency for emotional stimuli among at-risk youth.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalAmerican Journal of Drug and Alcohol Abuse
Volume41
Issue number2
DOIs
StatePublished - Mar 1 2015

Fingerprint

Parietal Lobe
Alcoholism
Alcohols
Amygdala
Alcohol Drinking
Oxygen
Brain

Keywords

  • Adolescence
  • Amygdala
  • At-risk youth
  • Brain
  • Fear
  • FMRI
  • Parietal
  • Substance use disorders

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism. / Peraza, Jennifer; Cservenka, Anita; Herting, Megan M.; Nagel, Bonnie.

In: American Journal of Drug and Alcohol Abuse, Vol. 41, No. 2, 01.03.2015, p. 139-145.

Research output: Contribution to journalArticle

@article{22da52da286747ff8d6f16aa2844ac42,
title = "Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism",
abstract = "Background: Adults with alcohol use disorders (AUDs) show different behavioral and neurological functioning during emotional processing tasks from healthy controls. Adults with a family history (FHP) of AUD also show different activation in limbic brain areas, such as the amygdala. However, it is unclear if this pattern exists during adolescence before any episodes of heavy alcohol use. Objectives: We hypothesized that the amygdalar response to subliminally-presented fearful faces would be reduced in FHP adolescents compared to peers who were family history negative (FHN) for AUD. Method: An adapted Masked Faces paradigm was used to examine blood oxygen level-dependent response to subliminal fearful vs. neutral faces in 14 FHP (6 females, 8 males) and 15 FHN (6 females, 9 males) youth, ages 11-15 years. Both FHP and FHN youth had no history of heavy alcohol consumption. Results: A significant difference was seen between groups in the left superior parietal lobule FHN youth showed deactivation to fearful and neutral masked faces compared to baseline, whereas FHP youth showed deactivation only to fearful masked faces. No significant differences in amygdalar activation were seen between groups. Conclusion: The left superior parietal lobule is part of the fronto-parietal network, which has been implicated in attentional control. Lack of reduced neural activity to neutral faces among FHP youth may represent differences in suppressing attention networks to less salient emotional stimuli, or perhaps, a higher threshold of saliency for emotional stimuli among at-risk youth.",
keywords = "Adolescence, Amygdala, At-risk youth, Brain, Fear, FMRI, Parietal, Substance use disorders",
author = "Jennifer Peraza and Anita Cservenka and Herting, {Megan M.} and Bonnie Nagel",
year = "2015",
month = "3",
day = "1",
doi = "10.3109/00952990.2014.953251",
language = "English (US)",
volume = "41",
pages = "139--145",
journal = "American Journal of Drug and Alcohol Abuse",
issn = "0095-2990",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism

AU - Peraza, Jennifer

AU - Cservenka, Anita

AU - Herting, Megan M.

AU - Nagel, Bonnie

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: Adults with alcohol use disorders (AUDs) show different behavioral and neurological functioning during emotional processing tasks from healthy controls. Adults with a family history (FHP) of AUD also show different activation in limbic brain areas, such as the amygdala. However, it is unclear if this pattern exists during adolescence before any episodes of heavy alcohol use. Objectives: We hypothesized that the amygdalar response to subliminally-presented fearful faces would be reduced in FHP adolescents compared to peers who were family history negative (FHN) for AUD. Method: An adapted Masked Faces paradigm was used to examine blood oxygen level-dependent response to subliminal fearful vs. neutral faces in 14 FHP (6 females, 8 males) and 15 FHN (6 females, 9 males) youth, ages 11-15 years. Both FHP and FHN youth had no history of heavy alcohol consumption. Results: A significant difference was seen between groups in the left superior parietal lobule FHN youth showed deactivation to fearful and neutral masked faces compared to baseline, whereas FHP youth showed deactivation only to fearful masked faces. No significant differences in amygdalar activation were seen between groups. Conclusion: The left superior parietal lobule is part of the fronto-parietal network, which has been implicated in attentional control. Lack of reduced neural activity to neutral faces among FHP youth may represent differences in suppressing attention networks to less salient emotional stimuli, or perhaps, a higher threshold of saliency for emotional stimuli among at-risk youth.

AB - Background: Adults with alcohol use disorders (AUDs) show different behavioral and neurological functioning during emotional processing tasks from healthy controls. Adults with a family history (FHP) of AUD also show different activation in limbic brain areas, such as the amygdala. However, it is unclear if this pattern exists during adolescence before any episodes of heavy alcohol use. Objectives: We hypothesized that the amygdalar response to subliminally-presented fearful faces would be reduced in FHP adolescents compared to peers who were family history negative (FHN) for AUD. Method: An adapted Masked Faces paradigm was used to examine blood oxygen level-dependent response to subliminal fearful vs. neutral faces in 14 FHP (6 females, 8 males) and 15 FHN (6 females, 9 males) youth, ages 11-15 years. Both FHP and FHN youth had no history of heavy alcohol consumption. Results: A significant difference was seen between groups in the left superior parietal lobule FHN youth showed deactivation to fearful and neutral masked faces compared to baseline, whereas FHP youth showed deactivation only to fearful masked faces. No significant differences in amygdalar activation were seen between groups. Conclusion: The left superior parietal lobule is part of the fronto-parietal network, which has been implicated in attentional control. Lack of reduced neural activity to neutral faces among FHP youth may represent differences in suppressing attention networks to less salient emotional stimuli, or perhaps, a higher threshold of saliency for emotional stimuli among at-risk youth.

KW - Adolescence

KW - Amygdala

KW - At-risk youth

KW - Brain

KW - Fear

KW - FMRI

KW - Parietal

KW - Substance use disorders

UR - http://www.scopus.com/inward/record.url?scp=84923371537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923371537&partnerID=8YFLogxK

U2 - 10.3109/00952990.2014.953251

DO - 10.3109/00952990.2014.953251

M3 - Article

VL - 41

SP - 139

EP - 145

JO - American Journal of Drug and Alcohol Abuse

JF - American Journal of Drug and Alcohol Abuse

SN - 0095-2990

IS - 2

ER -